Vaccine delivery: Overcoming the challenges of vaccinating livestock and wildlife

Veterinary Vaccine Pub Date : 2024-12-01 Epub Date: 2024-11-28 DOI:10.1016/j.vetvac.2024.100093
Freya A. Russell , Dietmar W. Hutmacher , Tim R. Dargaville , Kenneth W. Beagley
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Abstract

The hypodermic syringe and needle are the leading technology in vaccine administration as they provide immediate and direct dosing at a low cost. This is convenient for administration of initial and booster doses for humans, however, for livestock and wildlife, multiple doses can be problematic due to accessibility and housing issues. Devices for delayed/multi-dose delivery of vaccines are becoming increasingly popular as they have the potential to stimulate full immunity from a single injection and can be altered depending on the pathogen and target species. The current challenge with delayed/multi-dose delivery devices is that they are not progressing to commercial development for numerous reasons. This review aims to investigate currently research devices and examine how these devices can be implemented in livestock and wildlife populations.
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提供疫苗:克服为牲畜和野生动物接种疫苗的挑战
皮下注射器和针头是疫苗施用的主要技术,因为它们以低成本提供即时和直接的剂量。这对于人类初始剂量和加强剂量的施用是方便的,但对于牲畜和野生动物,由于可及性和住房问题,多次给药可能存在问题。延迟/多剂量递送疫苗的装置正变得越来越受欢迎,因为它们有可能从单次注射中刺激完全免疫,并且可以根据病原体和目标物种进行改变。延迟/多剂量给药装置目前面临的挑战是,由于种种原因,它们没有进入商业开发阶段。本综述旨在调查目前研究的设备,并研究如何在牲畜和野生动物种群中实施这些设备。
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