Design of nonanoic acid composite vesicles as cosmetics carrier: Stability, skin permeability, antioxidant and antibacterial activity

IF 5.3 2区化学 Q2 CHEMISTRY, PHYSICAL Journal of Molecular Liquids Pub Date : 2025-02-01 DOI:10.1016/j.molliq.2024.126772

Xinyu Fan , Ying Yang , Yuxi Gong , Yuqi Zhan , Xiangyu Zhang , Shi Zhou , Dongmei Wu

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引用次数: 0

Abstract

Based on the inherent alkaline adaptability of fatty acid vesicles (FAVs) when in contact with the human body, along with the very narrow pH window for the formation and application of FAVs, which is far from the physiological pH range, this study successfully prepared a composite vesicle of non-ionic surfactant Tween60 (TW60) with nonanoic acid (NA) to migrate and expand the pH window. Acid-base titration confirmed that adding varying proportions of TW60 to sodium nonanoate (SN) solutions expanded the pH window from 6.6–7.5 to 1.28–6.52, widening it by 5.24, as determined by conductivity and turbidity. Studies under different conditions such as ionic strength, temperature, and storage time indicated that NA/TW60-FAV exhibited excellent stability. At a myricetin (MYR) concentration of 1 mg/mL and a pH of 6, encapsulation efficiency (EE) was 93.03 ± 0.03 %, and the drug loading capacity (DLC) was 8.65 ± 0.02 %, reaching the highest values. In vitro release and skin permeation results indicated that compared to free MYR solution (1 mg/mL), the skin permeability of the MYR-loaded composite vesicles (NA/TW60/MYR-FAV) was 1.64 times that of the MYR solution, significantly increasing skin absorption and retention, with a pronounced sustained release effect. The antioxidant activity experiments confirmed a significant enhancement in its ability to scavenge DPPH, ferric ions, and hydroxyl radicals (OH). The antibacterial experiments showed that NA/TW60/MYR-FAV had significant inhibitory effects against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), indicating potential applications in cosmetics. In summary, the pH range of the blank composite vesicles (NA/TW60-FAV) aligns with the requirements for human skin adaptation, significantly enhancing the intrinsic value of the loaded substance. This indicates that it is a reliable and stable vesicle carrier, offering preliminary evidence for further research and application in the cosmetics industry.

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来源期刊

Journal of Molecular Liquids 化学-物理：原子、分子和化学物理

CiteScore

10.30

自引率

16.70%

发文量

2597

审稿时长

78 days

期刊介绍： The journal includes papers in the following areas: – Simple organic liquids and mixtures – Ionic liquids – Surfactant solutions (including micelles and vesicles) and liquid interfaces – Colloidal solutions and nanoparticles – Thermotropic and lyotropic liquid crystals – Ferrofluids – Water, aqueous solutions and other hydrogen-bonded liquids – Lubricants, polymer solutions and melts – Molten metals and salts – Phase transitions and critical phenomena in liquids and confined fluids – Self assembly in complex liquids.– Biomolecules in solution The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include: – Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.) – Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.) – Light scattering (Rayleigh, Brillouin, PCS, etc.) – Dielectric relaxation – X-ray and neutron scattering and diffraction. Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.