Design of nonanoic acid composite vesicles as cosmetics carrier: Stability, skin permeability, antioxidant and antibacterial activity

IF 5.2 2区化学 Q2 CHEMISTRY, PHYSICAL Journal of Molecular Liquids Pub Date : 2025-02-01 Epub Date: 2024-12-25 DOI:10.1016/j.molliq.2024.126772

Xinyu Fan , Ying Yang , Yuxi Gong , Yuqi Zhan , Xiangyu Zhang , Shi Zhou , Dongmei Wu

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Abstract

Based on the inherent alkaline adaptability of fatty acid vesicles (FAVs) when in contact with the human body, along with the very narrow pH window for the formation and application of FAVs, which is far from the physiological pH range, this study successfully prepared a composite vesicle of non-ionic surfactant Tween60 (TW60) with nonanoic acid (NA) to migrate and expand the pH window. Acid-base titration confirmed that adding varying proportions of TW60 to sodium nonanoate (SN) solutions expanded the pH window from 6.6–7.5 to 1.28–6.52, widening it by 5.24, as determined by conductivity and turbidity. Studies under different conditions such as ionic strength, temperature, and storage time indicated that NA/TW60-FAV exhibited excellent stability. At a myricetin (MYR) concentration of 1 mg/mL and a pH of 6, encapsulation efficiency (EE) was 93.03 ± 0.03 %, and the drug loading capacity (DLC) was 8.65 ± 0.02 %, reaching the highest values. In vitro release and skin permeation results indicated that compared to free MYR solution (1 mg/mL), the skin permeability of the MYR-loaded composite vesicles (NA/TW60/MYR-FAV) was 1.64 times that of the MYR solution, significantly increasing skin absorption and retention, with a pronounced sustained release effect. The antioxidant activity experiments confirmed a significant enhancement in its ability to scavenge DPPH, ferric ions, and hydroxyl radicals (OH). The antibacterial experiments showed that NA/TW60/MYR-FAV had significant inhibitory effects against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), indicating potential applications in cosmetics. In summary, the pH range of the blank composite vesicles (NA/TW60-FAV) aligns with the requirements for human skin adaptation, significantly enhancing the intrinsic value of the loaded substance. This indicates that it is a reliable and stable vesicle carrier, offering preliminary evidence for further research and application in the cosmetics industry.

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化妆品载体壬酸复合囊泡的设计：稳定性、透气性、抗氧化性和抗菌性

基于脂肪酸囊泡（fas）与人体接触时固有的碱性适应性，以及fas形成和应用的pH窗口非常窄，远离生理pH范围，本研究成功制备了非离子表面活性剂Tween60 （TW60）与壬酸（NA）的复合囊泡，以迁移和扩大pH窗口。酸碱滴定证实，通过电导率和浊度测定，在壬酸钠（SN）溶液中加入不同比例的TW60将pH窗口从6.6-7.5扩大到1.28-6.52，拓宽了5.24。对NA/TW60-FAV在离子强度、温度、贮存时间等不同条件下的稳定性研究表明，NA/TW60-FAV具有优异的稳定性。在杨梅素（MYR）浓度为1 mg/mL、pH为6时，包封率（EE）为93.03±0.03%，载药量（DLC）为8.65±0.02%，达到最高值。体外释放和皮肤渗透结果表明，与游离MYR溶液（1 mg/mL）相比，负载MYR的复合囊泡（NA/TW60/MYR- fav）的皮肤渗透性是MYR溶液的1.64倍，显著增加了皮肤吸收和滞留，并具有明显的缓释效果。抗氧化活性实验证实其清除DPPH、铁离子和羟基自由基（OH）的能力显著增强。抑菌实验表明，NA/TW60/MYR-FAV对大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）具有显著的抑制作用，在化妆品中具有潜在的应用前景。综上所述，空白复合囊泡（NA/TW60-FAV）的pH范围符合人体皮肤适应性要求，显著提高了负载物质的内在价值。这表明它是一种可靠、稳定的囊泡载体，为其在化妆品行业的进一步研究和应用提供了初步依据。

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来源期刊

Journal of Molecular Liquids 化学-物理：原子、分子和化学物理

CiteScore

10.30

自引率

16.70%

发文量

2597

审稿时长

78 days

期刊介绍： The journal includes papers in the following areas: – Simple organic liquids and mixtures – Ionic liquids – Surfactant solutions (including micelles and vesicles) and liquid interfaces – Colloidal solutions and nanoparticles – Thermotropic and lyotropic liquid crystals – Ferrofluids – Water, aqueous solutions and other hydrogen-bonded liquids – Lubricants, polymer solutions and melts – Molten metals and salts – Phase transitions and critical phenomena in liquids and confined fluids – Self assembly in complex liquids.– Biomolecules in solution The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include: – Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.) – Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.) – Light scattering (Rayleigh, Brillouin, PCS, etc.) – Dielectric relaxation – X-ray and neutron scattering and diffraction. Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.