Combatting multi-drug resistance in urinary tract infections among diabetic populations: A perspective review

Abstract

Diabetes mellitus (DM) is a chronic condition that lowers life expectancy and quality of life when left untreated or improperly managed. Infections, both common and pathogenic, such as emphysematous pyelonephritis, malignant otitis externa, mucormycosis, and Fournier's gangrene, are more common in diabetic patients. Because patients with diabetes have a lower prognosis and more frequent Urinary tract infections (UTIs) than those without diabetes. Based on the literature, we carried out a review study that examined the characteristics of the prevalence of UTIs among diabetic patients in various countries over time, as well as the associated risk factors, processes, and therapeutic issues. The results show that compared to people without diabetes, diabetic patients with UTIs have higher rates of hospitalization, recurrence, and mortality, as well as a more frequent evolution to bacteremia. Pregnancy, advanced age, multidrug-resistant bacteria, and the length of a patient's diabetes seem to be the potential risk factors that have been found. With rare exceptions, the antibiotic susceptibility profile and bacterial strains responsible for UTIs in patients with DM are similar to those in non-diabetics; nonetheless, careful selection of antimicrobial agents, and treatment duration should match that needed for complicated UTIs.