Health sciences review (Oxford, England)最新文献

Overview of outcomes measurement tools used to evaluate outpatient and home-based exercise-based pulmonary rehabilitation programs for COVID-19: A systematic review 用于评估COVID-19门诊和家庭运动肺康复方案的结果测量工具概述：一项系统综述

Health sciences review (Oxford, England)

Pub Date : 2026-01-21 DOI: 10.1016/j.hsr.2026.100262

Fabrice Gambaraza , Germain Perrin , Sven Günther , Virginie Korb-Savoldelli , Anne-Isabelle Tropeano , Thibaut Caruba , Sarah Berdot , Brigitte Sabatier

This systematic review summarizes outcome measurement tools used in studies on outpatient and home-based rehabilitation for COVID-19. MEDLINE, EMBASE, and PEDro were searched up to November 2025, to identify comparative studies evaluating exercise training programs in COVID-19 patients. Respiratory function measures were the primary outcomes, physical and cognitive/psychosocial outcomes being secondary endpoints. Randomized controlled trials (RCTs), quasi-experimental and observational studies in adults with COVID-19, both non-hospitalized and those after discharge, were included. Seventy-two studies were included: forty-six RCTs (63.9%), twenty-two before-after studies (30.6%), and other designs (5.6%, n = 4). Forty studies assessed home-based telerehabilitation via apps or online platforms (55.6%), eleven evaluated unsupervised home-based exercise (15.3%), twenty focused on outpatient rehabilitation centers (27.8%) and one (1.4%) evaluated a hybrid program. Most studies (69.4%) reported short-term interventions (≤ 2 months). Proportion of respiratory outcomes measures showing improvements post-intervention ranged from 0 to 100% (mean ± SD: 54.8 ± 39.6%), and physical outcome measures, from 0 to 100% (mean ± SD: 67.1 ± 39.9%). However, 65.3% of studies had a high risk of bias. The most reported outcome measures were the mMRC and spirometric parameters (respiratory function), the 6-MWD (physical function), and HADS and SF-36 (psychosocial function). Nevertheless, this review highlights the considerable heterogeneity of outcomes measures in outpatient and home-based rehabilitation studies for COVID-19. While potential benefits are suggested, conclusions are limited by methodological quality and inconsistent outcome reporting. These results emphasize the need for standardized outcome measurement tools sets to improve comparability and enable meta-analyses.

Trial registration: The study protocol has been registered in the PROSPERO database dated 26^th September 2022 (registration number CRD42022362933).

本系统综述总结了COVID-19门诊和家庭康复研究中使用的结果测量工具。检索到2025年11月的MEDLINE、EMBASE和PEDro，以确定评估COVID-19患者运动训练计划的比较研究。呼吸功能测量是主要终点，身体和认知/社会心理结果是次要终点。纳入了针对COVID-19成人（非住院和出院后）的随机对照试验（rct）、准实验和观察性研究。纳入72项研究：46项rct(63.9%)， 22项前后对照研究（30.6%）和其他设计（5.6%,n = 4）。40项研究评估了通过应用程序或在线平台进行的家庭远程康复（55.6%），11项研究评估了无监督的家庭锻炼（15.3%），20项研究关注门诊康复中心（27.8%），1项研究评估了混合项目（1.4%）。大多数研究（69.4%）报告了短期干预（≤2个月）。干预后显示呼吸结果改善的比例从0到100%（平均±SD: 54.8±39.6%），身体结果改善的比例从0到100%（平均±SD: 67.1±39.9%）。然而，65.3%的研究存在高偏倚风险。报告最多的结果测量是mMRC和肺活量测定参数（呼吸功能），6-MWD（身体功能），HADS和SF-36（社会心理功能）。然而，本综述强调了COVID-19门诊和家庭康复研究中结果测量的相当大的异质性。虽然提出了潜在的益处，但结论受到方法质量和结果报告不一致的限制。这些结果强调需要标准化的结果测量工具集，以提高可比性和实现荟萃分析。试验注册：研究方案已于2022年9月26日在PROSPERO数据库中注册（注册号CRD42022362933）。

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引用次数: 0

Pterostilbene: An influential neuronutraceutical to effectively counteract different neuropathologies 紫檀芪：一种有影响力的神经营养药物，能有效对抗不同的神经病变

Health sciences review (Oxford, England)

Pub Date : 2026-01-08 DOI: 10.1016/j.hsr.2026.100260

Surekha Kadannagari , Suhrud Pathak , Keyi Liu , Mary Liz Hill , Nicholas Roth , Anna Cate Tanner , Satyanarayana Pondugula , Muhammed Majeed , Kalyanam Nagabhushanam , Pooja a Chawla , Viney Chawla , Kamal Dua , Vetriselvan Subramaniyan , Muralikrishnan Dhanasekaran

Natural bioactive-based pharmacological treatments are now viewed as a promising long-term complement or alternative to conventional therapy. With its billions of neurons, the brain is a dynamic, intricate network that interacts to govern every bodily function. Neurodegenerative diseases can develop from the disruption of neuronal function, which is the fundamental unit of the nervous system. Growing data indicate a rise in brain-affecting conditions, which are nevertheless defined by limited treatment alternatives. The need to discover novel, non-invasive methods to stop the degeneration of neurons is crucial. Natural bioactives exhibit a diverse spectrum of chemical structures that can exert a range of pharmacological and toxicological effects, ultimately leading to neuroprotection or neurotoxicity. These pharmacodynamic qualities can have a beneficial or detrimental influence on global human and animal healthcare. Pterostilbene is a substance used in Greek, Chinese, and Ayurvedic medicine, well-known for its numerous therapeutic uses. The reported beneficial effects of resveratrol and pterostilbene have stimulated renewed scientific interest in recent years. Dimethyl ether analog of resveratrol, called Pterostilbene, is a naturally occurring bioactive that is metabolically stable and has demonstrated significant pharmacological actions. Resveratrol and pterostilbene share significant pharmacological similarities, and both are widely regarded as safe for human consumption. Most research focuses on resveratrol, with very few studies investigating pterostilbene. Thus, the current study has reviewed and included the neuro-nutraceutical value of Pterostilbene, which helps for preventive and therapeutic purposes for various neurological pathologies. Pterostilbene has been shown to be beneficial in treating various diseases affecting the central nervous system, according to research; however, there is a lack of clinical data regarding its effectiveness.

以天然生物活性为基础的药理学治疗现在被视为一种有希望的长期补充或替代传统治疗。大脑拥有数十亿个神经元，是一个动态的、复杂的网络，它相互作用，控制着身体的每一个功能。神经退行性疾病可以从神经功能的破坏发展，这是神经系统的基本单位。越来越多的数据表明，影响大脑的疾病有所增加，但这些疾病的治疗选择有限。发现新的、非侵入性的方法来阻止神经元的退化是至关重要的。天然生物活性物质表现出多种化学结构，可发挥一系列药理和毒理学作用，最终导致神经保护或神经毒性。这些药效学性质可对全球人类和动物保健产生有益或有害的影响。紫檀芪是希腊、中国和阿育吠陀医学中使用的一种物质，以其众多的治疗用途而闻名。近年来，有关白藜芦醇和紫檀芪的有益作用的报道再次激起了科学界的兴趣。白藜芦醇的二甲醚类似物，称为紫光芪，是一种天然存在的生物活性物质，代谢稳定，并已证明具有显著的药理作用。白藜芦醇和紫檀芪具有显著的药理相似性，两者都被广泛认为对人类食用是安全的。大多数研究都集中在白藜芦醇上，很少有研究调查紫檀芪。因此，本研究回顾并纳入了紫檀芪的神经营养价值，有助于预防和治疗各种神经系统疾病。根据研究，紫檀芪已被证明对治疗影响中枢神经系统的各种疾病有益；然而，缺乏关于其有效性的临床数据。

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引用次数: 0

Role of natural products in cardiovascular diseases 天然产物在心血管疾病中的作用

Health sciences review (Oxford, England)

Pub Date : 2026-01-08 DOI: 10.1016/j.hsr.2026.100259

Kiersten Ward , Laney Haas , Caroline Leeling , Luke Morgan , Peyton Jacobs , Suhrud Pathak , Keyi Liu , Pooja A Chawla , Alexander Chi Wang Siu , Kamal Dua , Vetriselvan Subramaniyan , Muralikrishnan Dhanasekaran , Viney Chawla

A potential new therapy and preventative option for cardiovascular diseases (CVD) is the use of natural ingredients.CVDs are a broad category of disorders that impact the heart and blood vessels, causing a substantial amount of morbidity and mortality on a global scale.The pathophysiology of CVD is examined in this article, with emphasis placed on important aspects like genetic mutations, atherosclerosis, and lifestyle choices that cause cardiac abnormalities.These flaws may affect blood flow and heart function, potentially leading to insufficient oxygen and nutrient delivery to critical organs.This study examines the diverse range of bioactive substances with cardioprotective properties that are extracted from plants, herbs, and other natural sources.Antioxidant effects, anti-inflammatory activity, lipid profile modification, and enhanced endothelial function are some of the main mechanisms of action.Specific substances emphasized for their roles in lowering hypertension, atherosclerosis, and myocardial ischemia include flavonoids, polyphenols, and omega-3 fatty acids.The articleemphasizes the significance of natural products in comprehensive cardiovascular care and explores how they can complement traditional therapies.We can improve methods for treating and preventing CVD by understanding the therapeutic potential of these natural chemicals.

一种潜在的新的治疗和预防心血管疾病（CVD）的选择是使用天然成分。心血管疾病是影响心脏和血管的一大类疾病，在全球范围内造成大量发病率和死亡率。本文研究了心血管疾病的病理生理学，重点放在基因突变、动脉粥样硬化和导致心脏异常的生活方式选择等重要方面。这些缺陷可能会影响血液流动和心脏功能，可能导致关键器官的氧气和营养输送不足。本研究考察了从植物、草药和其他天然来源中提取的具有心脏保护特性的各种生物活性物质。抗氧化作用、抗炎活性、脂质谱改变和增强内皮功能是一些主要的作用机制。在降低高血压、动脉粥样硬化和心肌缺血中发挥作用的特定物质包括类黄酮、多酚和omega-3脂肪酸。本文强调了天然产物在心血管综合护理中的重要性，并探讨了它们如何补充传统疗法。通过了解这些天然化学物质的治疗潜力，我们可以改进治疗和预防心血管疾病的方法。

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引用次数: 0

Insulin icodec: A once-weekly basal insulin on the horizon for diabetes management with implications for hospital care transitions 胰岛素icodec：每周一次的基础胰岛素在糖尿病管理的地平线上与医院护理转变的含义

Health sciences review (Oxford, England)

Pub Date : 2026-01-04 DOI: 10.1016/j.hsr.2026.100258

Kai Xu , Kimberly Hardin , Demi Lenox-Riccelli , Alpesh N. Amin

Once-weekly basal insulin brings with it the promise of reduced treatment burden and the potential to usher in a new era of diabetes care. Practical guidance is needed for this paradigm shift in insulin administration in real-world hospital settings. This narrative review summarizes efficacy and safety findings on the once-weekly basal insulin icodec from the ONWARDS global clinical trial program, relying on both systematic reviews and meta-analyses. We rely primarily on clinical trial data, which includes some limited real-world hospital data. We explore the potential opportunities for enhanced, long-acting insulin to facilitate the care of hospitalized patients and avoid hypoglycemia, as well as optimize care continuum goals, all important management strategies for hospital medicine physicians.

每周一次的基础胰岛素治疗有望减轻治疗负担，并有可能开创糖尿病治疗的新时代。实际的指导需要在现实世界的医院设置胰岛素管理的这种范式转变。本文基于系统综述和荟萃分析，总结了来自全球临床试验项目的每周一次基础胰岛素icodec的疗效和安全性发现。我们主要依靠临床试验数据，其中包括一些有限的真实医院数据。我们探索增强型长效胰岛素的潜在机会，以促进住院患者的护理，避免低血糖，以及优化护理连续性目标，这些都是医院内科医生的重要管理策略。

引用次数: 0

Neuroprotective effects of adiponectin in experimental models of ischemic stroke: A systematic review and meta-analysis 脂联素在缺血性卒中实验模型中的神经保护作用：一项系统综述和荟萃分析

Health sciences review (Oxford, England)

Pub Date : 2025-12-31 DOI: 10.1016/j.hsr.2025.100255

Sedigheh Behrouzifar , Habibollah Esmaily

Adiponectin, a pleiotropic adipokine, exerts neuroprotective actions in ischemic stroke through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms. This systematic review and meta-analysis synthesized preclinical evidence on the effects of adiponectin in experimental models of cerebral ischemia. A comprehensive search of PubMed, EMBASE, Scopus, and Google Scholar (1995–2024) identified rodent studies employing the middle cerebral artery occlusion (MCAO) model and reporting infarct volume or neurological outcomes. Following PRISMA 2020 guidelines and PROSPERO registration (CRD42023460289), two independent reviewers performed data extraction and risk-of-bias assessment. Eighteen eligible studies (n = 1309 animals) demonstrated that adiponectin markedly reduced infarct volume (SMD = –3.18; 95% CI: –4.12 to –2.25; p < 0.001; I² = 86%) and improved neurological scores (SMD = –2.17; 95% CI: –2.84 to –1.51; p < 0.001; I² = 82%), indicating a reduction in ischemic injury. Molecular analyses revealed lower levels of apoptotic (cleaved caspase-3, BAX, TUNEL-positive cells), inflammatory (IL-1β, TNF-α), and oxidative stress markers (ROS, MDA, 8-OHdG), alongside increased expression of neuroprotective proteins (BCL-2, SOD, p-AMPK, BDNF, VEGF, eNOS). Collectively, preclinical evidence supports the neuroprotective potential of adiponectin against ischemic brain injury. Nevertheless, study heterogeneity and low-to-moderate certainty of evidence highlight the need for standardized, adequately powered animal studies before translation to clinical settings.

脂联素是一种多效性脂肪因子，在缺血性卒中中通过抗氧化、抗炎和抗凋亡机制发挥神经保护作用。本系统综述和荟萃分析综合了脂联素在脑缺血实验模型中的作用的临床前证据。PubMed， EMBASE， Scopus和谷歌Scholar（1995-2024）的综合搜索发现，啮齿动物研究采用大脑中动脉闭塞（MCAO）模型并报告梗死体积或神经学结果。根据PRISMA 2020指南和PROSPERO注册（CRD42023460289），两位独立审稿人进行了数据提取和偏倚风险评估。18项符合条件的研究（n = 1309只动物）表明，脂联素显著减少梗死面积（SMD = -3.18; 95% CI: -4.12至-2.25;p < 0.001; I²= 86%），改善神经学评分（SMD = -2.17; 95% CI: -2.84至-1.51;p < 0.001; I²= 82%），表明缺血性损伤减少。分子分析显示，细胞凋亡（裂解caspase-3、BAX、tunel阳性细胞）、炎症（IL-1β、TNF-α）和氧化应激标志物（ROS、MDA、8-OHdG）水平降低，神经保护蛋白（BCL-2、SOD、p-AMPK、BDNF、VEGF、eNOS）表达增加。总的来说，临床前证据支持脂联素对缺血性脑损伤的神经保护潜力。然而，研究的异质性和证据的低至中等确定性突出了在转化为临床环境之前需要标准化，充分支持的动物研究。

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引用次数: 0

Severe malaria in Cameroon: a systematic review of a sticky problem and associated challenges to guide public health strategies in Africa 喀麦隆的严重疟疾：系统审查一个棘手问题和相关挑战，以指导非洲的公共卫生战略

Health sciences review (Oxford, England)

Pub Date : 2025-12-31 DOI: 10.1016/j.hsr.2025.100257

Loick P. Kojom Foko , Michel M. Yop Kite , Megane D. Malieuze Nanfah , Verónica M. Binam Nkot , Sandrine S. Beack Bayengue , Martin L. Koanga Mogtomo

Background

Severe malaria (SM) is a possible outcome of infection with Plasmodium spp. parasites. Cameroon, a malaria endemic country, has made enormous progress in the control of malaria over the last two decades; however, some points, such as SM, need to be better understood.

Methods

This systematic review presents a comprehensive and critical view of the existing Cameroonian literature on SM over the last 40 years, with the final objective to identify major challenges for Cameroon and Africa. Relevant databases (PubMed, Ovid, Scopus, Cochrane Library, and ClinicalTrials.gov) were queried to identify potentially eligible studies.

Results

The review identified 52 relevant studies. SM, only due to Plasmodium falciparum, is the main reason for hospitalisation, at varying rates (∼9.09 % – 66.3 %). Neurological disorders (i.e., cerebral malaria – 2.7 % - 100 %, convulsions – 24.6 % - 91.7 %, prostration – 5.5 % - 61.9 %, and impaired consciousness – 15.9 % - 56.3 %%) are the predominant SM signs, followed by other signs such as hyperpyrexia (∼36 % – 68.2 %) and severe malarial anaemia (∼14.9 % – 64.8 %). Atypical signs, including severe thrombocytopenia and abundant epistaxis, are also seen in SM.

Discussion

Addressing SM is a crucial step in tackling malaria, but some unexplored knowledge gaps, such as the clinical impact of concurrent bacterial infections, Epstein-Barr virus, pfhrp2 deletions, malnutrition, and the gut microbiome, should be addressed.

重度疟疾（SM）是疟原虫感染的可能结果。喀麦隆是一个疟疾流行国家，过去二十年来在控制疟疾方面取得了巨大进展；然而，有些观点，如SM，需要更好地理解。方法本系统综述对过去40年来喀麦隆现有的SM文献进行了全面和批判性的分析，最终目标是确定喀麦隆和非洲面临的主要挑战。检索相关数据库（PubMed、Ovid、Scopus、Cochrane Library和ClinicalTrials.gov）以确定可能符合条件的研究。结果本综述确定了52项相关研究。仅由恶性疟原虫引起的SM是住院的主要原因，比例各不相同（约9.09% - 66.3%）。神经系统疾病（即，脑型疟疾- 2.7% - 100%，抽搐- 24.6% - 91.7%，俯伏- 5.5% - 61.9%，意识受损- 15.9% - 56.3%）是主要的SM症状，其次是高热（~ 36% - 68.2%）和严重疟疾贫血（~ 14.9% - 64.8%）。不典型体征，包括严重的血小板减少症和大量出血，也见于SM。讨论解决SM是解决疟疾的关键一步，但是一些未被探索的知识空白，如并发细菌感染、爱泼斯坦-巴尔病毒、pfhrp2缺失、营养不良和肠道微生物群的临床影响，应该得到解决。

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引用次数: 0

Perceived benefits of nurses’ involvement in health policy: A regional narrative review from middle Eastern and South Asian countries 护士参与卫生政策的感知利益：来自中东和南亚国家的区域叙事审查

Health sciences review (Oxford, England)

Pub Date : 2025-12-30 DOI: 10.1016/j.hsr.2025.100256

Pooyan Ghorbani Vajargah, Poorya Takasi, Rasoul Tabari-Khomeiran

Background

: Nurses play a critical role in healthcare systems, yet their active involvement in health policymaking remains limited. Comprehending the advantages of such engagement can provide critical insights for the advancement of the nursing profession and the enhancement of health systems. The goal of this narrative review was to look at and combine the evidence that already exists about the perceived benefits of nurses' involvement in health policymaking within Middle Eastern and South Asian countries.

Methods

An extensive literature search was performed across various databases, including PubMed, Scopus, and Web of Science. Research published in English till June 2025 was evaluated. Inclusion criteria focused on studies that reported benefits of nurses’ involvement in health policy. Data from five eligible studies were analyzed.

Results

Six studies from Jordan, Iran, Egypt, and Pakistan met the inclusion criteria. Despite predominantly low levels of actual participation, nurses reported multiple perceived benefits of involvement in health policymaking. These benefits included individual-level development (such as skill acquisition, confidence building, and professional growth), contributions to public and population health, opportunities for communication and influence, and strengthened nursing autonomy and system performance. Qualitative findings also identified several facilitators such as collaboration, organizational support, and more accessible policy pathways that may enhance nurses’ engagement in policymaking.

Conclusion

Nurses in Middle Eastern and South Asian countries perceive clear personal, professional, and system-level benefits from participating in health policymaking, including skill development, increased confidence, and contributions to public health. Despite these recognized advantages, actual participation remains limited. Strengthening organizational and structural support may help translate these perceived benefits into greater policy engagement.

背景：护士在卫生保健系统中发挥着关键作用，但她们在卫生政策制定中的积极参与仍然有限。了解这种参与的优势可以为护理专业的进步和卫生系统的加强提供关键的见解。这篇叙述性综述的目的是研究并结合中东和南亚国家中已经存在的关于护士参与卫生政策制定的可感知益处的证据。方法在PubMed、Scopus、Web of Science等数据库中进行广泛的文献检索。对截至2025年6月发表的英文研究进行了评估。纳入标准侧重于报告护士参与卫生政策的益处的研究。分析了五项符合条件的研究的数据。结果来自约旦、伊朗、埃及和巴基斯坦的6项研究符合纳入标准。尽管护士的实际参与程度很低，但他们报告了参与卫生政策制定的多重好处。这些好处包括个人层面的发展（如技能获得、信心建立和专业成长）、对公众和人口健康的贡献、沟通和影响的机会，以及加强护理自主权和系统绩效。定性研究结果还确定了一些促进因素，如合作、组织支持和更容易获得的政策途径，这些因素可能会加强护士对政策制定的参与。结论中东和南亚国家的护士从参与卫生政策制定中获得了明确的个人、专业和系统层面的利益，包括技能发展、信心增强和对公共卫生的贡献。尽管有这些公认的优势，实际参与仍然有限。加强组织和结构上的支持可能有助于将这些看得见的好处转化为更大的政策参与。

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引用次数: 0

Comment on “Midlife substances use risk factors and cognitive disorder in late life: A systematic review using meta-analysis” 《中年物质使用危险因素与晚年认知障碍：荟萃分析系统综述》评论

Health sciences review (Oxford, England)

Pub Date : 2025-12-29 DOI: 10.1016/j.hsr.2025.100254

Sushma Narsing Katkuri , Varshini Vadhithala , Amit Singh Pawaia , Dhanya Dedeepya , Hariharan Srinivasan

引用次数: 0

Defining resilience for global healthcare workforce: A narrative review 定义全球医疗保健劳动力的弹性：叙述回顾

Health sciences review (Oxford, England)

Pub Date : 2025-12-27 DOI: 10.1016/j.hsr.2025.100252

Prachi Pundir , Shilpa Sadanand , Varadharajan Srinivasan , Anil G Jacob , Salim Sebaoui , Adeel Shareef , Oommen John , Ashish Manwar

The objectives of the review were to examine commonly used definitions of resilience in the healthcare domain, analyse these definitions through the socio-ecological framework and identify the different dimensions of resilience relevant to healthcare workers. A systematic search was conducted in the MEDLINE database, and screening was performed at two levels. Data were extracted from the selected studies using Excel spreadsheets.

Definitions of resilience were extracted from 54 included studies. The highest number of studies focused on health worker resilience (n = 35), followed by studies on the general population and organizational well-being (n = 19). Based on the socio-ecological model, the definitions of resilience at micro-, meso‑ and macro-levels were summarized. Resilience is the ability to adapt or recover from stressors using a positive approach to achieve well-being, and positive health and social outcomes. Similarly, resilience at the meso‑ and macro-levels, is the ability of an individual, community or systems to adapt to or withstand hardship, and even thrive despite adversity as well as recover from stressors using a positive approach to achieve favourable health outcomes before, during, after and beyond any given event. The analysed literature was closely aligned with the broader domain of healthcare systems.

This review provides a description of resilience through different dimensions such as time of occurrence of the event, and type of exposure or response. A systems-based approach is critical for comprehending and enhancing resilience, as opposed to reductionist definitions. This approach emphasizes integrating multiple disciplines to study and describe resilience, rather than seeking a single definition.

回顾的目的是检查医疗保健领域中常用的弹性定义，通过社会生态框架分析这些定义，并确定与医疗工作者相关的弹性的不同维度。在MEDLINE数据库中进行了系统搜索，并在两个层面进行筛选。使用Excel电子表格从选定的研究中提取数据。从纳入的54项研究中提取了弹性的定义。关注卫生工作者复原力的研究最多（n = 35），其次是关于一般人群和组织福祉的研究（n = 19）。基于社会生态模型，总结了弹性在微观、中观和宏观层面的定义。弹性是指采用积极的方法适应压力源或从压力源中恢复的能力，以实现幸福，以及积极的健康和社会成果。同样，中观和宏观层面的复原力是指个人、社区或系统适应或承受困难，甚至在逆境中茁壮成长，以及在任何特定事件发生之前、期间、之后和之后采用积极方法从压力源中恢复的能力，以取得有利的健康结果。所分析的文献与更广泛的医疗保健系统领域密切相关。本综述从事件发生的时间、暴露或反应的类型等不同维度对弹性进行了描述。基于系统的方法是理解和增强弹性的关键，而不是简化的定义。这种方法强调整合多个学科来研究和描述弹性，而不是寻求单一的定义。

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引用次数: 0

Prevalence and complications of diabetes mellitus in Uganda: A systematic review and meta-analysis 乌干达糖尿病患病率和并发症：一项系统回顾和荟萃分析

Health sciences review (Oxford, England)

Pub Date : 2025-12-26 DOI: 10.1016/j.hsr.2025.100253

Danladi Makeri , Emmanuel Eilu , Martin Odoki , Priscilla Peter Dilli , Ezera Agwu

Diabetes mellitus is a growing public health concern in Uganda, with rising prevalence and significant complications. However, the overall burden and regional distribution remain inadequately characterized. This systematic review and meta-analysis determined the pooled prevalence of Diabetes mellitus and its associated complications in Uganda to guide public health interventions. We searched PubMed, Embase, and Scopus databases and Google scholar search engine on the 4th of September 2024 using the keywords “Diabetes mellitus” and “Uganda” combined using the boolean operators AND and OR. The search was run with no restriction to study type or year of publication. Study identification, selection, and inclusion adhered to the PRISMA guidelines. Study quality was assessed using the Joanna Briggs Institute risk of bias checklist for prevalence studies, and data were synthesized using a random-effects meta-analysis. Heterogeneity was evaluated using the I² statistic, and publication bias was assessed using funnel plots and Egger’s regression test. Thirty-nine (39) Ugandan studies published between 1996 and 2024 were included in this study. All studies reported either prevalence or complications of Diabetes mellitus or both, and cumulatively recruited 52,111 respondents from different regions of the country. The pooled prevalence of Diabetes mellitus in Uganda is 7 % (95 % CI:5 - 10), 2 times higher than 2023 Uganda NCD Risk Factor STEPS Survey. The central region had the highest prevalence at 22 %, 4 and 7 times higher than the pooled prevalence in the eastern and western regions, respectively. Common complications included peripheral neuropathy 46.4 % (95 % CI: 31.8–61.6), hypertension 45 % (95 % CI: 30.9–59.6), visual impairment 28 % (95 % CI: 14.0–49.0), and diabetic foot ulcers 8.73 % (95 % CI: 3.8–18.8). We conclude that 1 in 14 Ugandans suffers Diabetes mellitus, and is at risk of visual impairment, peripheral neuropathy, hypertension, and diabetic foot ulcers. These findings highlight the urgent need for targeted public health interventions to reduce the burden of Diabetes mellitus and its complications in Uganda.

糖尿病是乌干达日益严重的公共卫生问题，发病率不断上升，并发症严重。但是，总体负担和区域分布仍然不充分。本系统综述和荟萃分析确定了乌干达糖尿病及其相关并发症的总患病率，以指导公共卫生干预措施。我们于2024年9月4日在PubMed， Embase和Scopus数据库和谷歌学者搜索引擎中使用与或布尔运算符组合关键词“Diabetes”和“Uganda”进行检索。搜索没有研究类型或出版年份的限制。研究鉴定、选择和纳入均遵循PRISMA指南。研究质量采用乔安娜布里格斯研究所流行病学研究的偏倚风险检查表进行评估，数据采用随机效应荟萃分析进行综合。异质性评价采用I²统计量，发表偏倚评价采用漏斗图和Egger回归检验。这项研究包括了1996年至2024年间发表的39项乌干达研究。所有研究都报告了糖尿病的患病率或并发症，或两者兼而有之，并累计从该国不同地区招募了52,111名受访者。乌干达糖尿病的总患病率为7% (95% CI:5 - 10)，比2023年乌干达非传染性疾病风险因素STEPS调查高2倍。中部地区患病率最高，为22%，分别是东部和西部地区总患病率的4倍和7倍。常见并发症包括周围神经病变46.4% (95% CI: 31.8-61.6)，高血压45% (95% CI: 30.9-59.6)，视力损害28% (95% CI: 14.0-49.0)，糖尿病足溃疡8.73% （95% CI: 3.8-18.8）。我们得出结论，每14个乌干达人中就有1人患有糖尿病，并且有视力障碍、周围神经病变、高血压和糖尿病足溃疡的风险。这些发现突出表明，迫切需要采取有针对性的公共卫生干预措施，以减轻乌干达糖尿病及其并发症的负担。

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引用次数: 0