Associations of diet and lifestyle with new-onset diabetes and major cardiovascular events: The cardiometabolic disease and cancer cohort (4C) study and mendelian randomization

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Journal of Functional Foods Pub Date : 2025-01-01 DOI:10.1016/j.jff.2024.106614

Yue-Yang Zhang , Pei-Dong Li , Bing-Xue Chen , Qin Wan

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Abstract

Background and Aim

At present, there is an absence of a widely accepted model for a healthy diet-lifestyle in China. Therefore, this study aims to provide novel evidence for the development of a healthier diet-lifestyle model specifically tailored to the Chinese population.

Methods and Results

Over the 10-year follow-up period of 7612 participants, 545 incident cases of diabetes and 308 incident cases of major cardiovascular events were documented. Cox regression analysis indicated that participants consuming 0–2 servings of milk per week had a reduced risk of diabetes, with a hazard ratio of 0.72 (0.56–0.92). In contrast, coffee consumption was associated with an increased risk of diabetes. Moderate consumption of carbonated drinks and fruit drink was linked to a decreased risk of major cardiovascular events. The RCS analysis and Mendelian randomization analysis yielded largely consistent results.

Conclusions

These research findings underscore the crucial role of maintaining appropriate dietary and lifestyle habits for overall health in adults.

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来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.