ZSM-5/PEG/DOX nanocarrier for pH-responsive doxorubicin release: Kinetic, isothermal, and cytotoxic studies

IF 4.8 3区材料科学 Q1 CHEMISTRY, APPLIED Microporous and Mesoporous Materials Pub Date : 2025-01-31 DOI:10.1016/j.micromeso.2025.113531

Mahin Broukanlou , Seyed Ali Hosseini , Yaghub Pazhang

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Abstract

The application of ZSM-5/PEG nanoparticles as a drug carrier for the adsorption and release of doxorubicinas an anti-cancer drug was investigated. ZSM-5 zeolite was pegylated at different ratios, and ZSM-5/PEG with a mass ratio of (10:4) exhibited the best drug loading and loading efficiency of 83 % (14 mg/g). The carrier showed pH-responsive behaviour, releasing 65 % of the drug at pH 5.6 and 21 % at pH 7.4. The differential scanning calorimetry (DSC) approved the thermal stability of ZSM-5/PEG carrier under body conditions. The absorption models revealed that drug absorption onto ZSM-5/PEG followed the Freundlich model (

R^{2}

= 0.93), indicating multilayered absorption of DOX on ZSM-5/PEG nanoparticles. Moreover, the results of kinetic studies confirmed that among the different kinetic models, the Korsmeyer-Peppas model effectively described the release behaviour from the carrier. The values of n and K for the Korsmeyer-Peppas model resulted in 0.22 and 0.36, respectively, indicating that doxorubicin release from ZSM-5/PEG nanocarrier had a slow releasing rate and followed Fick's law. MTT assay showed that loading the DOX on the ZSM-5/PEG nanoparticles increased their cytotoxic effects on the HCT-116 cell line by almost 10 times with the lowest IC₅₀ values(38.1, 10.4, and 2.33 μg/ml for 24 h, 48 h, and 72 h after treatment, respectively). The study found that ZSM-5/PEG/DOX has the potential to treat cancer as a pH-sensitive and slow-releasing drug.

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来源期刊

Microporous and Mesoporous Materials 化学-材料科学：综合

CiteScore

10.70

自引率

5.80%

发文量

649

审稿时长

26 days

期刊介绍： Microporous and Mesoporous Materials covers novel and significant aspects of porous solids classified as either microporous (pore size up to 2 nm) or mesoporous (pore size 2 to 50 nm). The porosity should have a specific impact on the material properties or application. Typical examples are zeolites and zeolite-like materials, pillared materials, clathrasils and clathrates, carbon molecular sieves, ordered mesoporous materials, organic/inorganic porous hybrid materials, or porous metal oxides. Both natural and synthetic porous materials are within the scope of the journal. Topics which are particularly of interest include: All aspects of natural microporous and mesoporous solids The synthesis of crystalline or amorphous porous materials The physico-chemical characterization of microporous and mesoporous solids, especially spectroscopic and microscopic The modification of microporous and mesoporous solids, for example by ion exchange or solid-state reactions All topics related to diffusion of mobile species in the pores of microporous and mesoporous materials Adsorption (and other separation techniques) using microporous or mesoporous adsorbents Catalysis by microporous and mesoporous materials Host/guest interactions Theoretical chemistry and modelling of host/guest interactions All topics related to the application of microporous and mesoporous materials in industrial catalysis, separation technology, environmental protection, electrochemistry, membranes, sensors, optical devices, etc.