An efficient hydrophobic modification strategy for enhancing collagen stability: Effect of lauric acidic N-hydroxysulfosuccinimide ester on the structure and properties of fish collagen
Cong Bai , Hao Jiang , Minggao Deng , Qingtian Gong , Peiyu Li , Wentao Liu
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引用次数: 0
Abstract
The hydrophobic modifications of collagen have emerged as effective approaches to endow collagen-based materials with enhanced structural stability and advanced functions, but the existing hydrophobic modification strategies are relatively inefficient and environmentally unfriendly due to the use of large quantities of organic solvents. It is highly appealing to develop a greener and more efficient strategy to prepare hydrophobically modified collagens (HMCs). Herein, the ester of N-hydroxysulfosuccinimide activated lauric acid (NHSS-LA) was prepared as a promising alternative hydrophobic modifier, which could be efficiently used in aqueous solutions for enhancing the structure and properties of HMCs and hydrophobically modified collagen fiber membranes (HMCFMs). The performance of HMCs and HMCFMs could be tuned through adjusting the dosages of NHSS-LA. Besides maintaining the triple helical structure and cytocompatibility of HMCs, the hydrophobic modification could improve the thermal stability of HMCs owing to the enhancement of hydrophobic associations between collagen molecules, which was closely related to collagen concentrations and modification rates. Furthermore, the water resistance, thermal stability, and enzymatic degradation stability of HMCFMs were significantly improved. This work provides an efficient strategy for modifying fish collagen and fabricating high-performance collagen-based materials.
期刊介绍：
Polymer Degradation and Stability deals with the degradation reactions and their control which are a major preoccupation of practitioners of the many and diverse aspects of modern polymer technology.
Deteriorative reactions occur during processing, when polymers are subjected to heat, oxygen and mechanical stress, and during the useful life of the materials when oxygen and sunlight are the most important degradative agencies. In more specialised applications, degradation may be induced by high energy radiation, ozone, atmospheric pollutants, mechanical stress, biological action, hydrolysis and many other influences. The mechanisms of these reactions and stabilisation processes must be understood if the technology and application of polymers are to continue to advance. The reporting of investigations of this kind is therefore a major function of this journal.
However there are also new developments in polymer technology in which degradation processes find positive applications. For example, photodegradable plastics are now available, the recycling of polymeric products will become increasingly important, degradation and combustion studies are involved in the definition of the fire hazards which are associated with polymeric materials and the microelectronics industry is vitally dependent upon polymer degradation in the manufacture of its circuitry. Polymer properties may also be improved by processes like curing and grafting, the chemistry of which can be closely related to that which causes physical deterioration in other circumstances.
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