CICADA (UCX): A novel approach for automated breast cancer classification through aggressiveness delineation

IF 3.1 4区 生物学 Q2 BIOLOGY Computational Biology and Chemistry Pub Date : 2025-04-01 Epub Date: 2025-01-31 DOI:10.1016/j.compbiolchem.2025.108368
Davinder Paul Singh , Tathagat Banerjee , Pawandeep Kour , Debabrata Swain , Yogendra Narayan
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The objective is to precisely delineate the malignant area from healthy tissues, facilitating reliable evaluation of tumor attributes like location, size, and form. Historically, manual segmentation by radiologists has been the benchmark; however, it is labor-intensive and susceptible to fluctuation among different observers and within the same observer. With the advancement of medical imaging technologies, there is an increasing demand for automated or semi-automatic systems capable of performing segmentation with efficiency and precision. These strategies seek to minimize human error, enhance reproducibility, and expedite diagnosis, so enabling prompt treatment. A significant problem in breast cancer segmentation is the variability in tumor morphology among various patients and imaging techniques. Neoplasms exhibit considerable variability in dimensions, morphology, and density, complicating the formulation of a universal approach. Moreover, elements like breast tissue density, which might hinder tumor appearance in mammograms, further complicate segmentation. A further barrier is the necessity for extensive, meticulously annotated datasets to train and test machine learning models, as medical picture annotation is labor-intensive and demands specialized expertise. Notwithstanding these obstacles, automated breast cancer segmentation has demonstrated significant potential in clinical applications. It assists radiologists in swiftly and precisely identifying questionable areas, resulting in earlier diagnosis and enhanced patient outcomes. Automated devices can aid in treatment planning by delivering accurate measures of tumor size and location, which are essential for establishing suitable surgical or radiation methods. This study addresses these limitations by introducing CICADA (UCX), which aims to enhance diagnostic precision and operational efficiency in clinical applications. The present study focuses on the creation and assessment of a sophisticated medical picture segmentation model, called Cheetah Inspired Convex Adaptive Discriminator Algorithm with Unet Convenet Xt CICADA (UCX), by contrasting it with the most advanced techniques currently in use. With a mean IOU of 96.34 %, a Dice Coefficient/F1-Score of 99.6461 %, and an AUC of 99.88 %, the suggested model performs quite well. The study incorporates various feature selection techniques like Particle Swarm Optimisation, Dragon Fly, Grey Wolf and our proposed novel technique named as CICADA (UCX). Through a thorough comparison analysis using many approaches, the paper highlights the advantages of CICADA (UCX) for medical picture segmentation. The study advances the area by offering fresh perspectives on segmentation accuracy, with a focus on obtaining a high Dice Coefficient/F1-Score. The results highlight how CICADA (UCX) has the ability to greatly improve medical image analysis and enable more precise and effective diagnosis. The CICADA (UCX) model, a revolutionary approach to medical picture segmentation, is presented in this study, which is a significant improvement over other existing technique. The model outperforms state-of-the-art methods in a thorough comparison investigation, showing higher performance across important assessment measures including mean IOU, Dice Coefficient/F1-Score, and AUC. Notably, the model scores a remarkable 99.6461 % Dice Coefficient/F1-Score, demonstrating accurate medical structural delineation. An important aspect of medical imaging applications is segmentation accuracy, which is greatly improved by this study. The results point to possible improvements in operational efficiency and diagnostic accuracy, which would be beneficial to patients as well as medical personnel. 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Abstract

Breast cancer remains one of the leading causes of mortality worldwide, with current classification and segmentation techniques often falling short in accurately distinguishing between benign and malignant cases. The study both emphasize the novel approach, CICADA (UCX), specifically designed for breast segmentation with a focus on delineating aggressiveness. While the title highlights segmentation, the abstract expands on this by detailing the model's effectiveness in enhancing diagnostic precision in classifying aggressive tumor characteristics. Breast cancer segmentation pertains to the delineation of malignant tissue borders in medical imaging. The objective is to precisely delineate the malignant area from healthy tissues, facilitating reliable evaluation of tumor attributes like location, size, and form. Historically, manual segmentation by radiologists has been the benchmark; however, it is labor-intensive and susceptible to fluctuation among different observers and within the same observer. With the advancement of medical imaging technologies, there is an increasing demand for automated or semi-automatic systems capable of performing segmentation with efficiency and precision. These strategies seek to minimize human error, enhance reproducibility, and expedite diagnosis, so enabling prompt treatment. A significant problem in breast cancer segmentation is the variability in tumor morphology among various patients and imaging techniques. Neoplasms exhibit considerable variability in dimensions, morphology, and density, complicating the formulation of a universal approach. Moreover, elements like breast tissue density, which might hinder tumor appearance in mammograms, further complicate segmentation. A further barrier is the necessity for extensive, meticulously annotated datasets to train and test machine learning models, as medical picture annotation is labor-intensive and demands specialized expertise. Notwithstanding these obstacles, automated breast cancer segmentation has demonstrated significant potential in clinical applications. It assists radiologists in swiftly and precisely identifying questionable areas, resulting in earlier diagnosis and enhanced patient outcomes. Automated devices can aid in treatment planning by delivering accurate measures of tumor size and location, which are essential for establishing suitable surgical or radiation methods. This study addresses these limitations by introducing CICADA (UCX), which aims to enhance diagnostic precision and operational efficiency in clinical applications. The present study focuses on the creation and assessment of a sophisticated medical picture segmentation model, called Cheetah Inspired Convex Adaptive Discriminator Algorithm with Unet Convenet Xt CICADA (UCX), by contrasting it with the most advanced techniques currently in use. With a mean IOU of 96.34 %, a Dice Coefficient/F1-Score of 99.6461 %, and an AUC of 99.88 %, the suggested model performs quite well. The study incorporates various feature selection techniques like Particle Swarm Optimisation, Dragon Fly, Grey Wolf and our proposed novel technique named as CICADA (UCX). Through a thorough comparison analysis using many approaches, the paper highlights the advantages of CICADA (UCX) for medical picture segmentation. The study advances the area by offering fresh perspectives on segmentation accuracy, with a focus on obtaining a high Dice Coefficient/F1-Score. The results highlight how CICADA (UCX) has the ability to greatly improve medical image analysis and enable more precise and effective diagnosis. The CICADA (UCX) model, a revolutionary approach to medical picture segmentation, is presented in this study, which is a significant improvement over other existing technique. The model outperforms state-of-the-art methods in a thorough comparison investigation, showing higher performance across important assessment measures including mean IOU, Dice Coefficient/F1-Score, and AUC. Notably, the model scores a remarkable 99.6461 % Dice Coefficient/F1-Score, demonstrating accurate medical structural delineation. An important aspect of medical imaging applications is segmentation accuracy, which is greatly improved by this study. The results point to possible improvements in operational efficiency and diagnostic accuracy, which would be beneficial to patients as well as medical personnel. This discovery has significance for improving medical picture segmentation techniques and promoting technological developments in medical imaging and computer-aided diagnosis.
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CICADA (UCX):一种通过侵袭性描述实现乳腺癌自动分类的新方法
乳腺癌仍然是世界范围内死亡的主要原因之一,目前的分类和分割技术往往无法准确区分良性和恶性病例。这项研究都强调了一种新颖的方法,CICADA (UCX),专门用于乳房分割,重点是描述攻击性。虽然标题强调了分割,但摘要通过详细介绍该模型在提高对侵袭性肿瘤特征分类的诊断精度方面的有效性,对此进行了扩展。乳腺癌分割涉及医学影像中恶性组织边界的划定。目的是精确地从健康组织中划定恶性区域,促进对肿瘤属性(如位置、大小和形式)的可靠评估。从历史上看,放射科医生的人工分割一直是基准;然而,它是劳动密集型的,在不同的观察者之间和同一观察者内部容易波动。随着医学成像技术的进步,对能够高效、精确地进行分割的自动化或半自动系统的需求越来越大。这些策略旨在最大限度地减少人为错误,提高可重复性,加快诊断,从而实现及时治疗。乳腺癌分割的一个重要问题是不同患者和成像技术之间肿瘤形态的可变性。肿瘤在尺寸、形态和密度上表现出相当大的可变性,使通用方法的制定复杂化。此外,乳腺组织密度等因素可能会阻碍乳房x光检查中肿瘤的出现,从而使分割更加复杂。另一个障碍是需要广泛的、精心注释的数据集来训练和测试机器学习模型,因为医学图片注释是劳动密集型的,需要专业知识。尽管存在这些障碍,自动化乳腺癌分割已经在临床应用中显示出巨大的潜力。它可以帮助放射科医生快速准确地识别有问题的区域,从而实现早期诊断并提高患者的治疗效果。自动化设备可以通过提供肿瘤大小和位置的精确测量来帮助制定治疗计划,这对于建立合适的手术或放疗方法至关重要。本研究通过引入CICADA (UCX)来解决这些局限性,旨在提高临床应用中的诊断精度和操作效率。本研究的重点是创建和评估一种复杂的医学图像分割模型,称为Cheetah启发凸自适应判别器算法与Unet convet Xt CICADA (UCX),通过与目前使用的最先进的技术进行对比。平均IOU为96.34 %,Dice系数/F1-Score为99.6461 %,AUC为99.88 %,该模型表现良好。该研究结合了多种特征选择技术,如粒子群优化、蜻蜓、灰狼和我们提出的新技术CICADA (UCX)。通过对多种方法的比较分析,突出了CICADA (UCX)在医学图像分割中的优势。该研究通过提供分割精度的新视角来推进该领域,重点是获得高Dice系数/F1-Score。研究结果表明,CICADA (UCX)能够极大地改善医学图像分析,使诊断更加精确和有效。CICADA (UCX)模型是一种革命性的医学图像分割方法,是对现有医学图像分割技术的重大改进。在全面的对比调查中,该模型优于最先进的方法,在包括平均IOU、Dice系数/F1-Score和AUC在内的重要评估指标上表现出更高的性能。值得注意的是,该模型的得分为99.6461 % Dice Coefficient/F1-Score,显示了准确的医疗结构描绘。医学成像应用的一个重要方面是分割精度,本研究极大地提高了分割精度。研究结果指出了可能提高操作效率和诊断准确性,这将有利于患者和医务人员。这一发现对于改进医学图像分割技术,促进医学成像和计算机辅助诊断技术的发展具有重要意义。
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来源期刊
Computational Biology and Chemistry
Computational Biology and Chemistry 生物-计算机:跨学科应用
CiteScore
6.10
自引率
3.20%
发文量
142
审稿时长
24 days
期刊介绍: Computational Biology and Chemistry publishes original research papers and review articles in all areas of computational life sciences. High quality research contributions with a major computational component in the areas of nucleic acid and protein sequence research, molecular evolution, molecular genetics (functional genomics and proteomics), theory and practice of either biology-specific or chemical-biology-specific modeling, and structural biology of nucleic acids and proteins are particularly welcome. Exceptionally high quality research work in bioinformatics, systems biology, ecology, computational pharmacology, metabolism, biomedical engineering, epidemiology, and statistical genetics will also be considered. Given their inherent uncertainty, protein modeling and molecular docking studies should be thoroughly validated. In the absence of experimental results for validation, the use of molecular dynamics simulations along with detailed free energy calculations, for example, should be used as complementary techniques to support the major conclusions. Submissions of premature modeling exercises without additional biological insights will not be considered. Review articles will generally be commissioned by the editors and should not be submitted to the journal without explicit invitation. However prospective authors are welcome to send a brief (one to three pages) synopsis, which will be evaluated by the editors.
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