Achievement of guideline targets among people with type 2 diabetes with eASCVD and high risk of ASCVD in the UAE: Results of the PACT-MEA-UAE cohort

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes research and clinical practice Pub Date : 2025-03-01 Epub Date: 2025-02-03 DOI:10.1016/j.diabres.2025.112030

Alaaeldin Bashier , Amrish Agrawal , Dinesh Dhanwal , Fatheya A. Awadi , Ghada Awada , Haitham Seifeldin , Hani Sabbour , Hazem Aly , Hussam Abusahmin , Hussien Heshmat , Touseef Azhar , Vani K. Warrier , Wael Almahmeed

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Abstract

Aim

The Prevalence of Atherosclerotic Cardiovascular Disease in Patients with Type 2 Diabetes across the Middle East and Africa (PACT-MEA) study compared cardiovascular disease (CVD) risk and 2021 ESC guidelines adherence between UAE and broader MEA region participants for enhanced type 2 diabetes mellitus (T2D) and atherosclerotic cardiovascular disease (ASCVD).

Methods

A survey of 385 physicians explored clinical decision-making factors. Chart reviews of 3726 participants classified ASCVD risk as per 2021 ESC guidelines and compared T2D target achievement in primary and secondary care centers.

Results

The survey highlighted factors influencing T2D management decisions, with most adhering to international guidelines. Among 542 UAE participants, 62.7 % were at high and 37.1 % at very high risk for ASCVD. Target HbA_1c was achieved 45 % UAE vs. 37 % in regionally, BP by 41 % vs. 30 %, LDL by 36 % vs. 30 %, BMI <25 kg/m² by 20 % vs. 15 %, SGLT2is use by 63 % vs. 37 % and GLP-1RAs use by 22 % vs. 13 %, respectively. No participants met all ESC-recommended targets for T2D.

Conclusion

Physicians followed international guidelines, considering patient history, drug efficacy, and HbA1c levels for diabetes and ASCVD risks. In UAE, <50 % of at-risk individuals with T2D met ESC targets. Cardioprotective medication use was higher in UAE.

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在阿联酋，伴有ASCVD和ASCVD高风险的2型糖尿病患者实现指南目标：PACT-MEA-UAE队列的结果

目的：中东和非洲2型糖尿病患者动脉粥样硬化性心血管疾病的患病率（PACT-MEA）研究比较了阿联酋和更广泛的MEA地区参与者对2型糖尿病（T2D）和动脉粥样硬化性心血管疾病（ASCVD）的心血管疾病（CVD）风险和2021年ESC指南的依从性。方法：对385名医师进行调查，探讨临床决策因素。根据2021年ESC指南，对3726名参与者进行了ASCVD风险分类，并比较了初级和二级保健中心的T2D目标实现情况。结果：调查突出了影响T2D管理决策的因素，大多数遵循国际准则。在542名阿联酋参与者中，62.7% %处于ASCVD高风险，37.1% %处于非常高风险。糖化血红蛋白目标达到45 %区域与37 %在阿联酋,BP的41 %与30 %,低密度脂蛋白,36 %与30 %,BMI 2×20 %与15 %,SGLT2is使用63 %和37 %和GLP-1Ras使用22 %与13 %,分别。没有参与者达到所有esc推荐的T2D指标。结论：医生遵循国际指南，考虑患者病史、药物疗效、糖尿病和ASCVD风险的HbA1c水平。在阿联酋,

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.