Zhengxin Tang , Anthony E. Felder , Mahnaz Shahidi
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引用次数: 0
Abstract
Blood flow regulation has been shown to be compromised in common ocular diseases, such as diabetic retinopathy and glaucoma. The capacity of the retinal vessels to regulate blood flow can potentially serve as an oculomics biomarker for evaluating ocular and systemic diseases. Pulse-propagated intravascular pressure waves cause deformations of the vessel walls, thus offering a means to interrogate vascular compliance. The purpose of the current study is to report a method for measuring retinal pulse-propagated wave velocity (rPWV) based on spectral analysis of pulsatile intensity waveforms in human circumpapillary retinal vasculature. Arterial and venous rPWV values, as well as inter-subject variabilities of rPWV in non-diabetic and diabetic subjects, are reported. Preliminary results demonstrated the feasibility of this method for measuring rPWV and its potential for assessment of vascular plasticity in response to blood flow changes due to ocular and systemic diseases.
期刊介绍：
Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured.
Research Areas include:
• Angiogenesis
• Biochemistry
• Bioengineering
• Biomathematics
• Biophysics
• Cancer
• Circulatory homeostasis
• Comparative physiology
• Drug delivery
• Neuropharmacology
• Microvascular pathology
• Rheology
• Tissue Engineering.
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