Chaoshan Zhao, Minshan Gan, Zhuoya Jiang, Zilan Lv, Wei Feng, Li Wang, Shunbo Li
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引用次数: 0
Abstract
A novel anisotropic nanoparticle structure consisting of a single gold nanorod and nanospheres is designed. The optical properties, especially the scattering under polarized light, are studied. The signal readout is conducted using dark-field microimaging techniques in a microfluidic chip. The formation of this novel structure is induced by the intermediate biomolecules. Therefore, it demonstrates potential applications in the ultrasensitive detection of biomarkers. As an example, the detection of vascular endothelial growth factor (VEGF165) is demonstrated, and the specificity is also investigated. This unique approach not only effectively reduces background interference but also provides a new approach for accurate sensing of targeted tumor markers.
期刊介绍：
As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.
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