Retrospective evaluation of the effect of xylazine infusion on survival to discharge in horses undergoing exploratory laparotomy for colic.

IF 1.4 2区农林科学 Q2 VETERINARY SCIENCES Veterinary anaesthesia and analgesia Pub Date : 2025-01-15 DOI:10.1016/j.vaa.2025.01.006

Rachel A Reed, Anna T Carroll, Stephanie C Dantino, Jane E Quandt, Michele Barletta, Daniel M Sakai

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Abstract

Objective: To determine the influence of xylazine infusion on survival to discharge and describe the associated intraoperative requirement for isoflurane, use of positive inotropes and vasopressors, and recovery time in horses undergoing exploratory laparotomy.

Study design: Retrospective cohort study.

Animals: A total of 352 horses.

Methods: Medical records of horses undergoing anesthesia for exploratory laparotomy from January 2018 to December 2023 were reviewed. Data collected included survival to discharge, results of diagnostic tests, end tidal isoflurane concentration (FE'Iso), use of vasopressors/inotropes, and duration of recovery in horses with (WX) or without (WOX) intraoperative xylazine infusion. For survival to discharge, univariable and multivariable logistic regression was performed adjusting for the effects of other infusions. For all other variables, descriptive statistics were performed.

Results: Survival to discharge was 80.6% and 78.5% for WX and WOX, respectively (p = 0.431). Mean ± standard deviation FE'Iso was 0.82 ± 0.21% and 0.94 ± 0.21% for WX and WOX, respectively. Dobutamine was given to 159/166 (95.8%) and 176/186 (94.6%) horses at a rate of 1 (0.1-3.0) μg kg^-1 minute^-1 and 1 (0.25-3.0) μg kg^-1 minute^-1 in WX and WOX, respectively. Norepinephrine infusion was given to 15/166 (9%) and 27/186 (15%) horses at a rate of 0.2 (0.025-0.4) μg kg^-1 minute^-1 and 0.2 (0.05-0.7) μg kg^-1 minute^-1 in WX and WOX, respectively. Median (range) recovery times were 70 (15-310) minutes and 75 (20-313) minutes for WX and WOX, respectively.

Conclusions: The use of xylazine as a part of a balanced anesthesia protocol in horses undergoing exploratory laparotomy did not negatively affect survival to discharge.

Clinical relevance: Xylazine infusion as part of a balanced anesthesia protocol appears promising based on this single-center study. Further research is required to fully explore the risks and benefits of xylazine infusions in this context.

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来源期刊

Veterinary anaesthesia and analgesia 农林科学-兽医学

CiteScore

3.10

自引率

17.60%

发文量

审稿时长

97 days

期刊介绍： Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome: the basic sciences; pathophysiology of disease as it relates to anaesthetic management equipment intensive care chemical restraint of animals including laboratory animals, wildlife and exotic animals welfare issues associated with pain and distress education in veterinary anaesthesia and analgesia. Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.