{"title":"Recent Advances on Electrocyclic Reactions in Complex Natural Product Synthesis: An Update","authors":"Ruyi Chen, Yanlin Liu, Hanfeng Ding","doi":"10.1039/d4qo02276a","DOIUrl":null,"url":null,"abstract":"Electrocyclic reactions represent a fundamental class of organic transformations that play a pivotal role in the synthesis of structurally intricate and biologically active natural products. These reactions adhere to the Woodward−Hoffmann rules, which elucidate the stereochemical outcomes based on the symmetry properties of the molecular orbitals involved. Characterized by their ability to dictate regio- and stereochemistry with high fidelity, electrocyclic reactions have proven to be a reliable and efficient method for assembling complex polycyclic frameworks. This review highlights recent advances in the application of electrocyclic reactions within the total synthesis of notable natural products. It also includes short sections on electrocyclic reactions in biosynthesis and key methodological developments in this area over recent years, aiming to complement existing reviews.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"84 1","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4qo02276a","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Electrocyclic reactions represent a fundamental class of organic transformations that play a pivotal role in the synthesis of structurally intricate and biologically active natural products. These reactions adhere to the Woodward−Hoffmann rules, which elucidate the stereochemical outcomes based on the symmetry properties of the molecular orbitals involved. Characterized by their ability to dictate regio- and stereochemistry with high fidelity, electrocyclic reactions have proven to be a reliable and efficient method for assembling complex polycyclic frameworks. This review highlights recent advances in the application of electrocyclic reactions within the total synthesis of notable natural products. It also includes short sections on electrocyclic reactions in biosynthesis and key methodological developments in this area over recent years, aiming to complement existing reviews.
期刊介绍：
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.
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