Efficacy of Frozen Section Technique as a Rapid Diagnostic Tool in the Diagnosis of Funisitis in Premature Deliveries.

IF 0.6 4区医学 Q4 PATHOLOGY Fetal and Pediatric Pathology Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI:10.1080/15513815.2025.2457617

P Sivathangam, D Srinivasamurthy, Vani Krishnamurthy

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Abstract

Introduction: Presence of leucocytic infiltration in perivascular area or in Wharton jelly indicates funisitis. While conventional histopathological examination is the gold standard, its time delay hampers timely intervention. The frozen section technique offers a rapid alternative, enabling clinicians to promptly manage preterm early onset sepsis.

Methods: This is a prospective study of 18 months. 125 preterms analyzed. Frozen sections and conventional sections of umbilical cord prepared and examined for inflammation by two researchers. Diagnostic accuracy of frozen sections versus conventional sections evaluated for sensitivity and specificity in detecting funisitis.

Results: The frozen section of the umbilical cord was 85.5% sensitive and 86.7% specific in diagnosing funisitis. The inter-rater agreement for diagnosing funisitis was 72.2%. Funisitis on frozen section was 82.2% sensitive and 26.3% specific in diagnosing neonatal sepsis.

Conclusion: Frozen section examination of umbilical cord has good diagnostic ability in detecting funisitis. The inter-rater agreement is substantial.

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冷冻切片技术作为快速诊断工具在早产儿输卵管炎诊断中的作用。

导言：血管周围区或华顿水母中出现白细胞浸润提示蕈性炎。虽然常规的组织病理学检查是金标准，但其时间延迟阻碍了及时干预。冷冻切片技术提供了一个快速的选择，使临床医生及时管理早产早发败血症。方法：这是一项18个月的前瞻性研究。分析125例早产。冷冻切片和常规脐带切片由两名研究人员准备和检查炎症。冷冻切片与常规切片的诊断准确性评估在检测真菌炎的敏感性和特异性。结果：脐带冰冻切片诊断生殖道炎的敏感性为85.5%，特异性为86.7%。诊断尿道炎的一致性为72.2%。在诊断新生儿败血症时，冰冻切片上的真菌炎的敏感性为82.2%，特异性为26.3%。结论：脐带冰冻切片检查对诊断滑膜炎有较好的诊断作用。评级机构之间的协议是实质性的。

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.