Time in targeted blood glucose range as an independent predictor of 28-Day mortality in ICU Patients: A retrospective study

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes research and clinical practice Pub Date : 2025-02-07 DOI:10.1016/j.diabres.2025.112033

Jian Zhao , Dan Huang , Shuang Hua , Xiangdong Huang , Yuanzhuo Chen , Yugang Zhuang

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Abstract

Objective

This study aimed to evaluate the relationship between time in targeted blood glucose range (TIR) and 28-day mortality in critically ill patients.

Methods

A retrospective cohort analysis was conducted using data from the MIMIC-IV database. Patients (n = 18,905) were stratified into four quartiles based on TIR values. The association between TIR and mortality was assessed using multivariable logistic regression models with adjustments for potential confounders.

Results

In the fully adjusted model, each percentage point increase in TIR was associated with a 1 % reduction in 28-day mortality risk (OR = 0.99, 95 % CI: 0.98–0.99, P < 0.001). Patients in the highest TIR quartile showed a 60 % lower mortality risk compared to those in the lowest quartile (OR = 0.40, 95 % CI: 0.22–0.74, P = 0.003). The predictive model demonstrated good discriminative ability (AUC = 0.7543).

Conclusion

Time in targeted blood glucose range is independently associated with 28-day mortality in ICU patients, suggesting its potential value as a metric for risk stratification and glycemic management optimization.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.