Baseline (derived) neutrophil-lymphocyte ratio associated with survival in gastroesophageal junction or gastric cancer treated with ICIs.

IF 3.5 3区医学 Q2 ONCOLOGY Frontiers in Oncology Pub Date : 2025-01-24 eCollection Date: 2025-01-01 DOI:10.3389/fonc.2025.1404695

Chengyang Yu, Hao Jiang, Liezhi Wang, Zufu Jiang, Chong Jin

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Abstract

Objective: We carried out the meta-analysis to determine the predictive value of baseline neutrophil to lymphocyte ratio (NLR) and derived neutrophil to lymphocyte ratio (dNLR) levels in patients with gastroesophageal junction or gastric cancer (GJGC) who underwent immune checkpoint inhibitor (ICI) treatment.

Methods: Eligible articles were obtained through PubMed, the Cochrane Library, EMBASE, and Google Scholar, until April 15, 2023. The clinical outcomes evaluated in this study encompassed overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR).

Results: A total of 24 articles with 2221 patients were included in this meta-analysis. The pooled results demonstrated that patients with high NLR levels had significantly poorer OS (HR: 1.860, 95% CI: 1.564-2.213, p < 0.001) and PFS (HR: 1.678, 95% CI: 1.354-2.079, p < 0.001), and lower ORR (OR: 0.754, 95% CI: 0.621-0.915, p = 0.004) and DCR (OR: 0.391, 95% CI: 0.262-0.582, p < 0.001). Besides, we also found that high dNLR levels were significantly associated with shorter OS (HR: 2.117, 95% CI: 1.590-2.820, p < 0.001) and PFS (HR: 1.803, 95% CI: 1.415-2.297, p < 0.001).

Conclusion: Low baseline (Derived) NLR has the potential to predict the good efficacy of ICIs and survival outcomes in patients with GJGC. (Derived) NLR could be useful in determining the optimal treatment strategies for these patients.

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基线（衍生）中性粒细胞-淋巴细胞比率与胃食管交界处或接受ICIs治疗的胃癌患者的生存率相关。

目的：我们进行荟萃分析，以确定基线中性粒细胞与淋巴细胞比值（NLR）和衍生中性粒细胞与淋巴细胞比值（dNLR）水平在接受免疫检查点抑制剂（ICI）治疗的胃食管结或胃癌（GJGC）患者中的预测价值。方法：截至2023年4月15日，通过PubMed、Cochrane图书馆、EMBASE和谷歌Scholar获得符合条件的文章。本研究评估的临床结果包括总生存期（OS）、无进展生存期（PFS）、客观缓解率（ORR）和疾病控制率（DCR）。结果：本荟萃分析共纳入24篇文献，共2221例患者。合并结果显示，NLR水平高的患者OS （HR: 1.860, 95% CI: 1.564-2.213, p < 0.001）和PFS （HR: 1.678, 95% CI: 1.354-2.079, p < 0.001）明显较差，ORR （OR: 0.754, 95% CI: 0.621-0.915, p = 0.004）和DCR （OR: 0.391, 95% CI: 0.262-0.582, p < 0.001）较低。此外，我们还发现高dNLR水平与较短的OS （HR: 2.117, 95% CI: 1.590-2.820, p < 0.001）和PFS （HR: 1.803, 95% CI: 1.415-2.297, p < 0.001）显著相关。结论：低基线（衍生）NLR有可能预测ICIs的良好疗效和GJGC患者的生存结果。（衍生）NLR可用于确定这些患者的最佳治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

6.20

自引率

10.60%

发文量

6641

审稿时长

14 weeks

期刊介绍： Cancer Imaging and Diagnosis is dedicated to the publication of results from clinical and research studies applied to cancer diagnosis and treatment. The section aims to publish studies from the entire field of cancer imaging: results from routine use of clinical imaging in both radiology and nuclear medicine, results from clinical trials, experimental molecular imaging in humans and small animals, research on new contrast agents in CT, MRI, ultrasound, publication of new technical applications and processing algorithms to improve the standardization of quantitative imaging and image guided interventions for the diagnosis and treatment of cancer.