Screening for HBV, HCV, TP and HIV in pregnant women from various ethnic groups in Yili, Xinjiang, China.

Abstract

Analyze the infection status of four blood-borne infectious diseases, namely hepatitis B, hepatitis C, syphilis, and acquired immune deficiency syndrome(AIDS), among pregnant women from different ethnic groups in Yili, Xinjiang. The objective is to assess the prevalence of four infectious diseases among pregnant women in this region and provide reference for the prevention and elimination of mother-to-child transmission. Pregnant women of Han and Uygur ethnicity who underwent prenatal screening at our outpatient clinic between 2016 and 2022 were selected for screening for hepatitis B virus surface antigen (HBsAg), antibody to hepatitis C virus (anti-HCV), antibody to treponema pallidum (anti-TP) and antibody to human immunodeficiency virus (anti-HIV) using an enzyme-linked immunosorbent assay (ELISA). A total of 13437 pregnant women were tested, aged between 18 and 47. The positive rate of four infectious disease markers in Han and Uygur pregnant women in this region was 6.97% (936/13437). The total positive rate of HBsAg was 6.44% (865/13437), among which the Han HBsAg positive rate was 6.63% (836/12608), and the HBsAg positive rate in Uygur was 3.63% (29/829) (χ2=12.673, P=0.000); the total positive rate of anti-HCV was 0.16% (21/13437), of which the anti-HCV positive rate of Han was 0.15% (19/12608), and anti-HCV positive rate in Uygur was 0.24% (2/829). (χ2=0.034, P=0.853); the total positive rate of anti-TP was 0.34% (46/13437), of which the positive rate of anti-TP in Han was 0.24% (30/12608), and the positive rate of anti-TP in Uygur 1.93% (16/829) (χ2=65.280, P=0.000); the total positive rate of anti-HIV was 0.03% (4/13437), of which Han nationality anti-HIV positive rate was 0% (0/12608), and the anti-HIV positive rate in Uygur was 0.48% (4/829) (P = 0.000). The positive rate of hepatitis B surface antibodies (anti-HBs) positive in Han nationality was 56.44% (7116/12608) and the positive rate of anti-HBs in Uygur was 41.62% (345/829) (χ2=65.219, P=0.000); the negative detection rate of Han nationality was 29.04% (3661/12608) and the Uygur all-negative detection rate was 46.20% (383/829) (χ2=104.352, P=0.000). Our results suggest that the difference in infection rates between Han and Uygur pregnant women in Yili, Xinjiang, may be related to the different genetic susceptibility among different ethnic groups.