Optimization and assessment of the metabolites from the Corrigiola telephiifolia Pourr. roots, using response surface methodology

Abstract

Corrigiola telephiifolia Pourr. is recognized for its health-promoting effects due to its rich bioactive compound content, particularly antioxidants. This study aimed to optimize the extraction of phenolic compounds from dried C. telephiifolia roots using various solvent combinations. A centroid simplex statistical approach was employed to evaluate the impact of different organic solvents—methanol, ethanol, and water—on extraction efficiency. The results indicated that a 50% methanol and 50% water binary combination yielded the highest total phenolic content, while an equal combination of methanol, ethanol, and water maximized total flavonoid content. Additionally, the hydromethanolic extract (50%, 50%) demonstrated the optimum antioxidant activity, with specific solvent mixtures enhancing DPPH scavenging activity and FRAP values. The optimized solvent proportions for total antioxidant capacity were 60.8% water, 30.3% ethanol, and 8.9% methanol. These findings suggest that the optimized extraction models are cost-effective and efficient, providing a valuable method for extracting high-quality phytocompounds.