{"title":"Chromones from stems of <i>Harrisonia perforata</i>.","authors":"Sakunchai Khumsubdee, Vilailak Prachyawarakorn, Chulabhorn Mahidol, Poonsakdi Ploypradith, Somsak Ruchirawat, Phanruethai Pailee","doi":"10.1080/14786419.2025.2462968","DOIUrl":null,"url":null,"abstract":"<p><p>Four new chromones, named harforamone A (<b>1</b>), harforamone B (<b>2</b>), harforamone C (<b>3</b>), and harforamone D (<b>4</b>), together with six known compounds (<b>5</b>-<b>10</b>) were isolated from the dichloromethane extract of the stems of <i>Harrisonia perforata</i>. The chemical structures of four new compounds were elucidated by spectroscopic analysis, including 1D, 2D NMR and HRESIMS data. The known compounds were identified by comparing their spectroscopic data with the previously reported data. Compounds <b>7</b> and <b>8</b> were isolated for the first time from the Rutaceae family. The <i>in vitro</i> cytotoxic activity against six human cancer cell lines of the tested compounds was evaluated, but none of them showed any significant activity; only perforamone C (<b>5</b>) showed moderate cytotoxicity against cervical cancer cell line (HeLa).</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.6000,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2462968","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Four new chromones, named harforamone A (1), harforamone B (2), harforamone C (3), and harforamone D (4), together with six known compounds (5-10) were isolated from the dichloromethane extract of the stems of Harrisonia perforata. The chemical structures of four new compounds were elucidated by spectroscopic analysis, including 1D, 2D NMR and HRESIMS data. The known compounds were identified by comparing their spectroscopic data with the previously reported data. Compounds 7 and 8 were isolated for the first time from the Rutaceae family. The in vitro cytotoxic activity against six human cancer cell lines of the tested compounds was evaluated, but none of them showed any significant activity; only perforamone C (5) showed moderate cytotoxicity against cervical cancer cell line (HeLa).
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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