Naphthalene derivatives and diarylheptanoids from the leaves of Cyclocarya paliurus and their α-glucosidase inhibitory activities.

IF 1.6 3区 化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2025-02-11 DOI:10.1080/14786419.2025.2462963
Si-Yang Huang, Pan-Pan Zhang, Meng-Xia Yan, Yang-Yang Wang, Mei-Lan Yu, De-Kai Wang, Bo Yang
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Abstract

A phytochemical study of the leaves of Cyclocarya paliurus led to the discovery of five naphthalene derivatives (1-5) and two diarylheptanoids (6-7), among which compounds 1 and 6 are new natural products. The structural elucidation of these new compounds was achieved through an in-depth examination of spectroscopic data, including NMR, MS, and IR. Their absolute configurations were established using electronic circular dichroism (ECD) calculation and dimolybdenum tetraacetate-induced circular dichroism CD (ICD) experiments. Notably, compound 7 exhibited inhibitory activity against α-glucosidase, demonstrating an IC50 value of 14.5 ± 3.3 µM.

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白环己烷叶萘衍生物和二芳基庚烷及其α-葡萄糖苷酶抑制活性。
通过对环己烷叶片的植物化学研究,发现了5个萘衍生物(1-5)和2个二芳基庚烷(6-7),其中化合物1和6是新的天然产物。这些新化合物的结构解析是通过深入检查光谱数据实现的,包括核磁共振、质谱和红外光谱。通过电子圆二色性(ECD)计算和四乙酸二钼诱导圆二色性CD (ICD)实验确定了它们的绝对构型。值得注意的是,化合物7对α-葡萄糖苷酶具有抑制活性,IC50值为14.5±3.3µM。
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来源期刊
Natural Product Research
Natural Product Research 化学-医药化学
CiteScore
5.10
自引率
9.10%
发文量
605
审稿时长
2.1 months
期刊介绍: The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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