A natural biological adhesive from slug mucus for wound repair

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL Bioactive Materials Pub Date : 2025-02-13 DOI:10.1016/j.bioactmat.2025.01.030

Zhengchao Yuan , Siyuan Wu , Liwen Fu , Xinyi Wang , Zewen Wang , Muhammad Shafiq , Hao Feng , Lu Han , Jiahui Song , Mohamed EL-Newehy , Meera Moydeen Abdulhameed , Yuan Xu , Xiumei Mo , Shichao Jiang

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Abstract

Slugs could secrete mucus with multifunctional characteristics, such as reversible gelation, mucoadhesiveness, and viscoelasticity, which can be harnessed for multifaceted biotechnological and healthcare applications. The dried mucus (DM) was prepared using slug, which can be adhered to the tissue surface through different types of interactions (lap-shear force, 1.1 N for DM-3 group). The DM-3 further exhibited the highest hemostatic ability as discerned in a liver trauma injury model (hemostasis time, <15 s), biocompatibility and biodegradability (an insignificant residue at 4 weeks) in vivo, and considerably improved skin repair in full-thickness excisional wounds (wound closure, 96.2 % at day 14). Taken together, slug's mucus can be easily prepared with an economic and an eco-friendly method, which may have broad biotechnological and healthcare implications and potential utility in other related disciplines. This transition from natural components to the biomaterial may provide an invaluable platform for different types of applications.

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从鼻涕虫黏液中提取的天然生物黏合剂，用于伤口修复

鼻涕虫可以分泌具有多种功能特征的粘液，如可逆凝胶性、黏附性和粘弹性，可用于多方面的生物技术和医疗保健应用。用鼻涕虫制备干燥黏液（DM），通过不同类型的相互作用（搭剪力，DM-3组1.1 N）粘附在组织表面。DM-3在肝外伤损伤模型中表现出最高的止血能力（止血时间，15秒），生物相容性和生物降解性（4周后无明显残留），并显著改善全层切除伤口的皮肤修复（伤口愈合，第14天96.2%）。综上所述，鼻涕虫黏液可以很容易地以经济和环保的方法制备，这可能具有广泛的生物技术和医疗保健意义，并在其他相关学科中具有潜在的用途。这种从天然成分到生物材料的转变可能为不同类型的应用提供宝贵的平台。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.