Nonclogging Liquid-Walled Continuous Flow Reactors

IF 3.5 3区化学 Q2 CHEMISTRY, APPLIED Organic Process Research & Development Pub Date : 2025-02-12 DOI:10.1021/acs.oprd.4c00459

Alejandro Mata, Caroline de Fraipont, Céline Hervieux, Lucas Giacchetti, Oicime Hadj-Sassi, Alexandra Bogicevic, Vincent Marichez, Thomas M. Hermans

引用次数: 0

Abstract

Flow chemistry is rapidly growing as it can outperform batch processes in terms of production costs, product quality, and overall environmental footprint. However, the reaction scope in flow is currently restricted due to solid handling limitations. Solids such as heterogeneous catalysts (powders) or precipitates are known to clog flow reactors, leading to periods of downtime to clean (or sometimes even replace) the reactor. Here, we report on liquid-walled continuous flow reactors that are virtually insensitive to clogging (or abrasion) and mix an order of magnitude faster than do solid-wall analogs. Our walls consist of chemically inert ferrofluids that are held in place with permanent magnets, leading to a stable liquid–liquid interface. We show efficient formylation of aryl bromides that is normally plagued by in-line precipitation.

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无堵塞液壁连续流反应器

流动化学正在迅速发展，因为它在生产成本、产品质量和整体环境足迹方面优于批量工艺。然而，由于固体处理的限制，目前流动中的反应范围受到限制。众所周知，非均相催化剂（粉末）或沉淀物等固体会堵塞流动反应器，导致需要停机一段时间来清洁（有时甚至更换）反应器。在这里，我们报道了液壁连续流反应器，它实际上对堵塞（或磨损）不敏感，并且比固体壁类似物的混合速度快一个数量级。我们的墙壁由化学惰性铁磁流体组成，这些铁磁流体被永久磁铁固定在适当的位置，从而形成稳定的液-液界面。我们展示了芳基溴的有效甲酰化，这通常受到在线沉淀的困扰。

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.