Nonclogging Liquid-Walled Continuous Flow Reactors

IF 3.1 3区化学 Q2 CHEMISTRY, APPLIED Organic Process Research & Development Pub Date : 2025-02-12 DOI:10.1021/acs.oprd.4c00459

Alejandro Mata, Caroline de Fraipont, Céline Hervieux, Lucas Giacchetti, Oicime Hadj-Sassi, Alexandra Bogicevic, Vincent Marichez, Thomas M. Hermans

引用次数: 0

Abstract

Flow chemistry is rapidly growing as it can outperform batch processes in terms of production costs, product quality, and overall environmental footprint. However, the reaction scope in flow is currently restricted due to solid handling limitations. Solids such as heterogeneous catalysts (powders) or precipitates are known to clog flow reactors, leading to periods of downtime to clean (or sometimes even replace) the reactor. Here, we report on liquid-walled continuous flow reactors that are virtually insensitive to clogging (or abrasion) and mix an order of magnitude faster than do solid-wall analogs. Our walls consist of chemically inert ferrofluids that are held in place with permanent magnets, leading to a stable liquid–liquid interface. We show efficient formylation of aryl bromides that is normally plagued by in-line precipitation.

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.