Weight loss and asthma control: A systematic review of randomized controlled trials.

IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Reviews Pub Date : 2025-02-12 DOI:10.1111/obr.13907
Mahdieh Abbasalizad Farhangi, George Doumat, Isis F Baroni, Carlos A Camargo
{"title":"Weight loss and asthma control: A systematic review of randomized controlled trials.","authors":"Mahdieh Abbasalizad Farhangi, George Doumat, Isis F Baroni, Carlos A Camargo","doi":"10.1111/obr.13907","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In the current systematic review and meta-analysis, we evaluated the possible role of weight loss on asthma control, quality of life (QOL), and clinical outcomes among patients with asthma.</p><p><strong>Methods: </strong>We performed a systematic search of PubMed, CINAHL, and OVID Medline for randomized controlled human trials that examined the effects of weight loss on asthma control, QOL, and spirometry results, from 1 January 2000 to 31 December 2023. Twelve eligible studies (total n = 1052 participants) were included. Weighted mean differences (WMD) and 95% confidence intervals (CIs) were used to evaluate the effect size. Subgroup analyses and meta-regression approaches were performed to reveal possible sources of heterogeneity. Fractional polynomial modeling was performed to assess non-linear associations.</p><p><strong>Results: </strong>Weight loss reduced ACQ score (WMD -0.67 [95%CIs - 1.20, -0.13], P = 0.02; I<sup>2</sup> 91.3%, P < 0.001), and improved forced expiratory volume percent predicted (FEV)1<sub>pp</sub> (WMD 13.08 [95%CIs 2.42, 23.73], P = 0.02; I<sup>2</sup> 94.1%, P < 0.001) among patients with asthma. In a dose-response analysis, a significant non-linear association was reported between change in weight and changes in FEV1<sub>pp</sub> (P<sub>non-linearity</sub> = 0.01). The effects of weight loss on QOL (WMD 0.53 [-0.38, 1.44], P = 0.25; I<sup>2</sup> 95.6%, P < 0.001) and forced vital capacity percent predicted (FVC <sub>pp</sub>, WMD 4.90 [-3.22, 13.02], P = 0.24; I<sup>2</sup> 91.4%, P < 0.001) were not statistically significant.</p><p><strong>Conclusion: </strong>Weight loss improves asthma control and FEV1<sub>pp</sub> among patients with asthma in a two-class meta-analysis. Because of the relatively low number of well-designed clinical trials (n = 12), further trials are needed to better define the beneficial effects of weight loss on asthma control.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13907"},"PeriodicalIF":8.0000,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity Reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/obr.13907","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

Abstract

Background: In the current systematic review and meta-analysis, we evaluated the possible role of weight loss on asthma control, quality of life (QOL), and clinical outcomes among patients with asthma.

Methods: We performed a systematic search of PubMed, CINAHL, and OVID Medline for randomized controlled human trials that examined the effects of weight loss on asthma control, QOL, and spirometry results, from 1 January 2000 to 31 December 2023. Twelve eligible studies (total n = 1052 participants) were included. Weighted mean differences (WMD) and 95% confidence intervals (CIs) were used to evaluate the effect size. Subgroup analyses and meta-regression approaches were performed to reveal possible sources of heterogeneity. Fractional polynomial modeling was performed to assess non-linear associations.

Results: Weight loss reduced ACQ score (WMD -0.67 [95%CIs - 1.20, -0.13], P = 0.02; I2 91.3%, P < 0.001), and improved forced expiratory volume percent predicted (FEV)1pp (WMD 13.08 [95%CIs 2.42, 23.73], P = 0.02; I2 94.1%, P < 0.001) among patients with asthma. In a dose-response analysis, a significant non-linear association was reported between change in weight and changes in FEV1pp (Pnon-linearity = 0.01). The effects of weight loss on QOL (WMD 0.53 [-0.38, 1.44], P = 0.25; I2 95.6%, P < 0.001) and forced vital capacity percent predicted (FVC pp, WMD 4.90 [-3.22, 13.02], P = 0.24; I2 91.4%, P < 0.001) were not statistically significant.

Conclusion: Weight loss improves asthma control and FEV1pp among patients with asthma in a two-class meta-analysis. Because of the relatively low number of well-designed clinical trials (n = 12), further trials are needed to better define the beneficial effects of weight loss on asthma control.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Obesity Reviews
Obesity Reviews 医学-内分泌学与代谢
CiteScore
19.30
自引率
1.10%
发文量
130
审稿时长
1 months
期刊介绍: Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities. Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field. The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.
期刊最新文献
Prevalence of overweight and obesity in incarcerated individuals in developed and developing countries: A systematic review and meta-analysis. Weight loss and asthma control: A systematic review of randomized controlled trials. Health literacy and obesity: A systematic scoping review. Monosodium glutamate: A hidden risk factor for obesity? Issue Information
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1