The effect of dietary weight-loss interventions on the inflammatory markers interleukin-6 and TNF-alpha in adults with obesity: A systematic review and meta-analysis of randomized controlled clinical trials.
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Abstract
Background: A chronic inflammatory state characterizes a wide range of diseases for which obesity is a risk factor. Weight loss could reduce levels of circulating inflammatory markers potentially reducing the incidence of associated diseases and improving response to treatment. However, dietary weight loss studies have reported inconsistent effects on serum inflammatory makers and the long-term effects are unknown.
Objective: To systematically review randomized controlled trials and analyze any differences in serum interleukin-6 and tumor necrosis factor-alpha between adults with obesity achieving weight loss through dietary intervention compared to those receiving none or standard care.
Methods: Studies were identified by searching databases from 1966 to November 2024. Randomized controlled trials with at least 12 months' follow-up were included in this systematic review and meta-analysis with an assessment of Cochrane risk of bias version 1.
Results: Twelve eligible studies were included. No trials reported a significant effect of weight loss on circulating tumor necrosis factor-alpha, whilst studies achieving greater than 5% weight loss significantly reduced circulating interleukin-6 in adults with obesity.
Conclusion: Weight loss interventions achieving and maintaining greater than 5% weight loss appear to be required to reduce circulating interleukin-6 levels in adults with obesity.
期刊介绍：
Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities.
Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field.
The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.
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