The relationship between frailty and major adverse cardiovascular and cerebrovascular events in Chinese older adults: the mediating effect of lipid accumulation products.

IF 3.2 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Archives of Public Health Pub Date : 2025-02-12 DOI:10.1186/s13690-025-01520-8

Zhoucheng Kang, Yongli Ye, Hao Xiao, Lingling Liu

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Abstract

Background: Previous studies have proven the relationship between frailty and major adverse cardiovascular and cerebrovascular events (MACCE). However, the potential mechanisms need to be further explored. This study aimed to investigate the mediating effect of lipid accumulation products (LAP) in the relationship between frailty and MACCE.

Methods: This study recruited 7901 participants aged 45 and above from wave 2011 and 2018 of the China Longitudinal Study of Health and Retirement (CHARLS). Logistic regression models were employed to examine the relationship between frailty and MACCE and the mediating effects of LAP, using the bootstrap method to confirm path effects.

Results: Frailty group presented the highest risk of MACCE (OR 1.07, 95% CI 1.03-1.10). Frailty directly impacted MACCE (β = 0.045, P = 0.007). Frailty had a significant effect on LAP (β = 12.21, P < 0.01), while LAP had a significant impact on MACCE (β = 11.14, p = 0.014). The mediation effect of LAP accounted for 1.7% of the total effect regarding the frailty with MACCE.

Conclusion: LAP mediate the relationship between frailty and MACCE. Our findings suggest that instructing frailty patients to have a reasonable diet and exercise to control LAP at a low level may be an effective measure to reduce MACCE.

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中国老年人虚弱与主要心脑血管不良事件的关系：脂质积累产物的中介作用。

背景：先前的研究已经证实了虚弱与主要心脑血管不良事件（MACCE）之间的关系。然而，潜在的机制需要进一步探索。本研究旨在探讨脂质积累产物（LAP）在衰弱与MACCE之间的中介作用。方法：本研究从2011年和2018年中国健康与退休纵向研究（CHARLS）中招募7901名45岁及以上的参与者。采用Logistic回归模型检验脆弱性与MACCE的关系以及LAP的中介效应，采用自举法确认路径效应。结果：虚弱组MACCE风险最高（OR 1.07, 95% CI 1.03-1.10）。虚弱直接影响MACCE （β = 0.045, P = 0.007）。虚弱对LAP有显著影响（β = 12.21， P）。结论：LAP介导了虚弱与MACCE的关系。提示指导体弱多病患者合理饮食和运动，将LAP控制在较低水平，可能是降低MACCE的有效措施。

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来源期刊

Archives of Public Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.80

自引率

3.00%

发文量

244

审稿时长

16 weeks

期刊介绍： rchives of Public Health is a broad scope public health journal, dedicated to publishing all sound science in the field of public health. The journal aims to better the understanding of the health of populations. The journal contributes to public health knowledge, enhances the interaction between research, policy and practice and stimulates public health monitoring and indicator development. The journal considers submissions on health outcomes and their determinants, with clear statements about the public health and policy implications. Archives of Public Health welcomes methodological papers (e.g., on study design and bias), papers on health services research, health economics, community interventions, and epidemiological studies dealing with international comparisons, the determinants of inequality in health, and the environmental, behavioural, social, demographic and occupational correlates of health and diseases.