{"title":"Study on the Mechanism of Benziothiazolinone and Its Synergistic Effect with Tebuconazole in Inhibiting <i>Fusarium asiaticum</i> and DON Production.","authors":"Xing Chen, Chuchu Liu, Weiye Liu, Jiawei Yang, Chunyan Gu, Yang Sun, Haiqun Cao, Yu Chen","doi":"10.1021/acs.jafc.4c12428","DOIUrl":null,"url":null,"abstract":"<p><p>Fusarium head blight (FHB), caused by the <i>Fusarium graminearum</i> species complex, is a devastating disease of wheat and other cereal crops. This study investigates the antifungal mechanism of the novel fungicide benziothiazolinone (BIT) against <i>Fusarium asiaticum</i> (Fa) and its synergistic effect with tebuconazole (TB). BIT could inhibit NADH and ATP production and lead to mitochondrial fragmentation, thereby inhibiting the mycelial growth of Fa. Besides, BIT mixing with TB at 1:1 showed an obvious synergistic effect against Fa based on mycelial growth and could significantly inhibit reactive oxygen species and DON productions, toxisome formation, as well as the expression of DON biosynthesis-related genes <i>tri1</i>, <i>tri5</i>, and <i>tri6</i>. In addition, field experiments showed that BIT mixing with TB exhibited 77.63% efficacy in FHB control and 51.92% efficacy in DON contamination. Taken together, this study highlights the synergistic effects of BIT and TB in FHB control and toxin management.</p>","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":" ","pages":"4947-4957"},"PeriodicalIF":6.2000,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Agricultural and Food Chemistry","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1021/acs.jafc.4c12428","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/14 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"AGRICULTURE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Fusarium head blight (FHB), caused by the Fusarium graminearum species complex, is a devastating disease of wheat and other cereal crops. This study investigates the antifungal mechanism of the novel fungicide benziothiazolinone (BIT) against Fusarium asiaticum (Fa) and its synergistic effect with tebuconazole (TB). BIT could inhibit NADH and ATP production and lead to mitochondrial fragmentation, thereby inhibiting the mycelial growth of Fa. Besides, BIT mixing with TB at 1:1 showed an obvious synergistic effect against Fa based on mycelial growth and could significantly inhibit reactive oxygen species and DON productions, toxisome formation, as well as the expression of DON biosynthesis-related genes tri1, tri5, and tri6. In addition, field experiments showed that BIT mixing with TB exhibited 77.63% efficacy in FHB control and 51.92% efficacy in DON contamination. Taken together, this study highlights the synergistic effects of BIT and TB in FHB control and toxin management.
赤霉病（Fusarium head blight， FHB）是小麦和其他谷类作物的一种毁灭性病害，由谷草赤霉病（Fusarium graminearum）菌种群引起。研究了新型杀菌剂苯并噻唑啉酮（BIT）对亚洲镰刀菌（Fa）的抑菌机理及其与替布康唑（TB）的协同作用。BIT可以抑制NADH和ATP的产生，导致线粒体断裂，从而抑制Fa的菌丝生长。此外，BIT与TB按1:1的比例混合对菌丝生长具有明显的协同作用，可以显著抑制活性氧和DON的产生、毒体的形成以及DON生物合成相关基因tri1、tri5和tri6的表达。此外，田间试验表明，BIT与TB混合对FHB的控制效果为77.63%，对DON的控制效果为51.92%。综上所述，本研究强调了结核分枝杆菌和结核分枝杆菌在食品血红蛋白控制和毒素管理中的协同作用。
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The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.
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