Trogocytosis of CARs depends on transmembrane domains

IF 60.9 1区 医学 Q1 IMMUNOLOGY Nature Reviews Immunology Pub Date : 2025-02-14 DOI:10.1038/s41577-025-01146-5
Alexandra Flemming
{"title":"Trogocytosis of CARs depends on transmembrane domains","authors":"Alexandra Flemming","doi":"10.1038/s41577-025-01146-5","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"156-156"},"PeriodicalIF":60.9000,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41577-025-01146-5","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
car细胞的穴居作用依赖于跨膜结构域
免疫细胞可以通过水平蛋白转移交换膜结合分子,这是一个鲜为人知的过程,称为胞浆作用。Barbera等人现在表明嵌合抗原受体(CAR)工程T细胞可以在体内通过细胞吞噬作用将其CAR转移到T细胞和其他细胞中。受体T细胞上的car似乎是功能性的,因为分离的受体细胞能够杀死靶细胞。像以前提出的那样,Trogocytosis并不依赖于转移蛋白的同源结合伙伴。相反,水平CAR转移的概率是由其跨膜结构域及其定位到微绒毛尖端的可能性决定的。这些发现对CAR的设计具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Nature Reviews Immunology
Nature Reviews Immunology 医学-免疫学
CiteScore
93.40
自引率
0.40%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.
期刊最新文献
The long-lived immune system of centenarians. Lymphocyte-mediated immune responses to Leishmania infection. Pathophysiological roles of monocytes and macrophages in cancer. Metabolite and nutrient regulation of macrophages in obesity and metabolic disease. Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1