Xiaoran Min , Junping Chen , Wenhao Mu , Jiayi Huang , Guozheng Huang , Jianguo Cao
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引用次数: 0
Abstract
One new sesquiterpenoid (1) and eighteen known natural compounds (2–19) were obtained from the aerial parts of Ajania fruticulosa. Their structures were established by spectroscopic methods, and the absolute configurations were further determined by single-crystal X-ray diffraction analysis for compounds 1 and 3. Compound 1 is a guaianolide-type dimeric sesquiterpenoid which might be a product of [4 + 2] addition reaction between compound 3 and its 1,2-dehydro analogue. Compound 12 showed a potent xanthine oxidase (XOD) inhibitory activity (IC50 value of 23.82 ± 0.35 μM) and acted as a mixed-type inhibitor of XOD. Compounds 12 and 13 showed low toxicity while significantly inhibiting LPS-induced NO production in RAW264.7 cells.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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