Regulation of non-emotional memory through α1-adrenergic receptors activation: A short review

IF 2.9 Q3 NEUROSCIENCES IBRO Neuroscience Reports Pub Date : 2025-06-01 Epub Date: 2025-02-14 DOI:10.1016/j.ibneur.2025.02.005

Eugénia Correia de Barros

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Abstract

The α₁ adrenergic receptors (α₁-ARs) play a central role in the regulation of synaptic plasticity and memory, but their role in non-emotional memory is still poorly understood. This review summarizes recent advances in understanding the functions of α₁-ARs and highlights their contributions to synaptic efficacy, long-term potentiation (LTP), and long-term depression (LTD) in the hippocampus and neocortex. There is evidence that α₁-AR activation occurs through intracellular pathways such as Gq-protein signaling, MAPK, and cAMP cascades. Furthermore, α₁-ARs are emerging as promising therapeutic targets in neurodegenerative diseases, including Alzheimer’s disease (AD), due to their capability to modulate cognition and neuronal plasticity. New insights into positive allosteric modulators (PAMs) that cross the blood-brain barrier provide a potential avenue for safer and more effective therapies. This review highlights the need for further research to improve the understanding of α₁-ARs and their potential for memory enhancement and neuroprotection.

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α1-肾上腺素能受体激活对非情绪记忆的调节：综述

α1肾上腺素能受体（α1- ars）在突触可塑性和记忆的调节中发挥核心作用，但其在非情绪记忆中的作用尚不清楚。本文综述了α1-ARs在海马和新皮层突触效能、长期增强（LTP）和长期抑制（LTD）等方面的研究进展。有证据表明α1-AR的激活是通过细胞内通路发生的，如gq蛋白信号，MAPK和cAMP级联。此外，α1-ARs由于其调节认知和神经元可塑性的能力，正成为包括阿尔茨海默病（AD）在内的神经退行性疾病的有希望的治疗靶点。对穿越血脑屏障的正变构调节剂（pam）的新见解为更安全、更有效的治疗提供了潜在的途径。这一综述强调需要进一步研究以提高对α1-ARs及其在记忆增强和神经保护方面的潜力的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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