{"title":"Structural determination of two undescribed triterpenoids from Punica granatum L. peels","authors":"Tomoki Iguchi, Norika Shibata, Hiyoka Ito, Tamami Shimazaki, Yoshihiro Mimaki","doi":"10.1016/j.phytol.2025.02.005","DOIUrl":null,"url":null,"abstract":"<div><div>Seven triterpenoids (<strong>1</strong>–<strong>7</strong>) comprising four oleanane-type (<strong>1</strong>–<strong>4</strong>), two ursane-type (<strong>5</strong> and <strong>6</strong>), and one lupane-type (<strong>7</strong>), were isolated from <em>Punica granatum</em> L. peels. The structures of two undescribed compounds (<strong>1</strong> and <strong>2</strong>) were elucidated primarily by two-dimensional NMR spectroscopic analysis. This is the first reported isolation of <strong>3</strong>, <strong>6</strong>, and <strong>7</strong> from <em>P. granatum</em>. The cytotoxicity of <strong>1</strong>–<strong>7</strong> was evaluated in SBC-3 human small-cell lung cancer cells using a modified 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2-tetrazolium bromide assay. Compounds <strong>3</strong>–<strong>7</strong> exhibited moderate cytotoxicity against SBC-3 cells, with IC<sub>50</sub> values ranging from 52 to 61 μM.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"66 ","pages":"Pages 54-59"},"PeriodicalIF":1.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390025010171","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/15 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Seven triterpenoids (1–7) comprising four oleanane-type (1–4), two ursane-type (5 and 6), and one lupane-type (7), were isolated from Punica granatum L. peels. The structures of two undescribed compounds (1 and 2) were elucidated primarily by two-dimensional NMR spectroscopic analysis. This is the first reported isolation of 3, 6, and 7 from P. granatum. The cytotoxicity of 1–7 was evaluated in SBC-3 human small-cell lung cancer cells using a modified 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2-tetrazolium bromide assay. Compounds 3–7 exhibited moderate cytotoxicity against SBC-3 cells, with IC50 values ranging from 52 to 61 μM.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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