A novel therapeutic approach for hormonal imbalance in polycystic ovarian syndrome; evaluating the effects of Nutrition Bio-Shield Supplement in an animal model

Abstract

Background

s: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that disrupts hormone balance, leading to infertility and metabolic issues. This study evaluates the effects of a novel nutritional supplement, Nutrition Bio-Shield (NBS), on hormonal regulation in a letrozole-induced PCOS rat model.

Methods

Twenty-five female Wistar rats were assigned to five groups: healthy control, PCOS control, and three groups treated with varying doses of NBS (12.5 mg/kg, 25 mg/kg, and 50 mg/kg). PCOS was induced using letrozole, and NBS was administered for 21 days. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, progesterone, and estradiol were measured using radioimmunoassay.

Results

NBS treatment significantly improved hormone levels compared to the PCOS control group. The highest dose (50 mg/kg) effectively reduced LH and testosterone while increasing progesterone and estradiol levels (p < 0.05), nearing those of the healthy controls. The 25 mg/kg dose also showed considerable improvement in hormone balance, whereas the 12.5 mg/kg dose had a moderate effect. FSH levels were notably reduced in both 50 mg/kg and 25 mg/kg groups, suggesting a dose-dependent response to NBS treatment.

Conclusion

NBS supplementation successfully ameliorated hormonal imbalances in a PCOS rat model, demonstrating its potential as a natural therapeutic option for managing PCOS. Further research is needed to confirm these effects in clinical settings.