Altered corticostriatal connectivity in long-COVID patients is associated with cognitive impairment.

IF 5.5 2区医学 Q1 PSYCHIATRY Psychological Medicine Pub Date : 2025-02-17 DOI:10.1017/S0033291725000054

Marie Troll, Meng Li, Tara Chand, Marlene Machnik, Tonia Rocktäschel, Antonia Toepffer, Johanna Ballez, Kathrin Finke, Daniel Güllmar, Jürgen R Reichenbach, Martin Walter, Bianca Besteher

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Abstract

Background: The COVID-19 pandemic has had a significant impact on the health of millions of people worldwide, and many manifest new or persistent symptoms long after the initial onset of the infection. One of the leading symptoms of long-COVID is cognitive impairment, which includes memory loss, lack of concentration, and brain fog. Understanding the nature and underlying mechanisms of cognitive impairment in long-COVID is important for developing preventive and therapeutic interventions.

Methods: Our present study investigated functional connectivity (FC) changes in patients with long-COVID and their associations with cognitive impairment. Resting-state functional MRI data from 60 long-COVID patients and 52 age- and sex-matched healthy controls were analyzed using seed-based functional connectivity analysis.

Results: We found increased FC between the right caudate nucleus and both the left and right precentral gyri in long-COVID patients compared with healthy controls. In addition, elevated FC was observed between the right anterior globus pallidus and posterior cingulate cortex as well as the right temporal pole in long-COVID patients. Importantly, the magnitude of FC between the caudate and the left precentral gyrus showed a significant negative correlation with Montreal Cognitive Assessment (MoCA) scores and a negative correlation with Trail Making Test B performance in the patient group.

Conclusion: Patients with long-COVID present enhanced FC between the caudate and the left precentral gyrus. Furthermore, those FC alterations are related to the severity of cognitive impairment, particularly in the domain of executive functions.

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长期covid患者皮质纹状体连通性的改变与认知障碍有关。

背景：2019冠状病毒病大流行对全世界数百万人的健康产生了重大影响，许多人在初次感染后很长时间仍出现新的或持续的症状。长期covid的主要症状之一是认知障碍，包括记忆丧失、注意力不集中和脑雾。了解长期covid认知功能障碍的性质和潜在机制对于制定预防和治疗干预措施具有重要意义。方法：本研究探讨长冠肺炎患者的功能连接（FC）变化及其与认知障碍的关系。使用基于种子的功能连通性分析分析了60例长期covid患者和52例年龄和性别匹配的健康对照者的静息状态功能MRI数据。结果：我们发现，与健康对照相比，长期covid患者右尾状核与左右中央前回之间的FC增加。此外，长冠患者右侧苍白球前部与后扣带皮层以及右侧颞极之间的FC升高。重要的是，在患者组中，尾状核和左中央前回之间的FC大小与蒙特利尔认知评估（MoCA）得分呈显著负相关，与Trail Making Test B的表现呈负相关。结论：长期covid患者尾状核和左中央前回之间FC增强。此外，这些FC的改变与认知障碍的严重程度有关，特别是在执行功能领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychological Medicine 医学-精神病学

CiteScore

11.30

自引率

4.30%

发文量

711

审稿时长

3-6 weeks

期刊介绍： Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.