Xiaolin Liu , Jinda Hou , Lang Wang , Jing Yu , Xuewen Hou , Luning Zhou , Falei Zhang , Qian Che , Tianjiao Zhu , Dehai Li , Guojian Zhang
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引用次数: 0
Abstract
A NRPKS gene cluster cic in Aspergillus nidulans was activated by overexpression of the pathway-specific transcriptional factor CicD. Large-scale fermentation and chemical investigation of the engineered strain A. nidulans A1145/cicD led to the discovery of two new isoindolone-amino acid adducts, isoleucylcichorine () and leucylcichorine (), along with three known derivatives. The structures of the new compounds were clearly determined by nuclear magnetic resonance (NMR) analysis, high-resolution electrospray ionization mass spectrometry (HRESIMS), and electronic circular dichroism (ECD) calculations. This study revealed that the overexpression of the pathway-specific transcriptional factor represents a promising approach for the discovery of new natural products in fungi.
期刊介绍：
Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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