Physiological adaptations of clinical vs. indoor environmental strains of Pseudomonas aeruginosa in a hospital setting.

IF 2.2 4区生物学 Q3 MICROBIOLOGY Fems Microbiology Letters Pub Date : 2025-02-17 DOI:10.1093/femsle/fnaf027

Gabriela Vasco, Ruth Martínez, Diego Noboa, Karla Vasco, Gabriel Trueba

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Abstract

Pseudomonas aeruginosa is a remarkably adaptive bacterium frequently implicated in severe, sometimes fatal infections within healthcare institutions. The origins of clinical strains have generated considerable debate, suggesting that infectious variants emerge through selection from a broader environmental bacterial population. Our investigation explored the physiological differences between environmental (indoor) and clinical strains of P. aeruginosa isolated from a hospital over a year. We assessed various parameters, including survival patterns, antibiotic resistance, vulnerability to ciliate predation, bacterial antagonism, and motility. Despite the minimal incidence of patient infections during our observation, environmental P. aeruginosa was prevalent throughout the hospital during our study. Clinical strains exhibited diminished resistance to certain antibiotics, increased resistance against ciliate predators, and enhanced swarming and swimming motility compared to their environmental counterparts. Clinical strains maintained higher cell densities under starvation conditions but were outcompeted by environmental strains in a nutrient medium. In conclusion, our study suggests that P. aeruginosa clinical isolates possess unique physiological adaptations that may favor host colonization.

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来源期刊

Fems Microbiology Letters 生物-微生物学

CiteScore

4.30

自引率

0.00%

发文量

112

审稿时长

1.9 months

期刊介绍： FEMS Microbiology Letters gives priority to concise papers that merit rapid publication by virtue of their originality, general interest and contribution to new developments in microbiology. All aspects of microbiology, including virology, are covered. 2019 Impact Factor: 1.987, Journal Citation Reports (Source Clarivate, 2020) Ranking: 98/135 (Microbiology) The journal is divided into eight Sections: Physiology and Biochemistry (including genetics, molecular biology and ‘omic’ studies) Food Microbiology (from food production and biotechnology to spoilage and food borne pathogens) Biotechnology and Synthetic Biology Pathogens and Pathogenicity (including medical, veterinary, plant and insect pathogens – particularly those relating to food security – with the exception of viruses) Environmental Microbiology (including ecophysiology, ecogenomics and meta-omic studies) Virology (viruses infecting any organism, including Bacteria and Archaea) Taxonomy and Systematics (for publication of novel taxa, taxonomic reclassifications and reviews of a taxonomic nature) Professional Development (including education, training, CPD, research assessment frameworks, research and publication metrics, best-practice, careers and history of microbiology) If you are unsure which Section is most appropriate for your manuscript, for example in the case of transdisciplinary studies, we recommend that you contact the Editor-In-Chief by email prior to submission. Our scope includes any type of microorganism - all members of the Bacteria and the Archaea and microbial members of the Eukarya (yeasts, filamentous fungi, microbial algae, protozoa, oomycetes, myxomycetes, etc.) as well as all viruses.