Determination of Minimum Alveolar Concentrations of Isoflurane and Effective Plasma Concentration of Propofol in Common Marmosets (Callithrix jacchus)

IF 0.8 4区农林科学 Q3 VETERINARY SCIENCES Journal of Medical Primatology Pub Date : 2025-02-19 DOI:10.1111/jmp.70006

Kanako Muta, Makoto Koizumi, Takako Miyabe-Nishiwaki, Yusuke Sotomaru, Asako Nobukiyo, Hiroki Ohta, Hirotaka James Okano, Masatoshi Kamata, Dai Nagakubo, Ryohei Nishimura

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Abstract

Background

Common marmosets (Callithrix jacchus) have been widely used as laboratory animals; However, limited sedation and anesthetic protocols have yet to be established. In this study, the minimum alveolar concentration of an inhalant (isoflurane) and effective predicted plasma concentration of an injectable anesthetic (propofol) were measured for optimization of sedation and anesthetic protocols in marmosets.

Methods

The minimum alveolar concentrations (MACs) for several stimulations (nociceptive stimulation, endotracheal intubation, and non-painful direct stimulation), MAC-noci, MAC-extb, and MAC-awake, respectively, were measured for isoflurane with the up-and-down method from four healthy marmosets. Predicted plasma concentrations 50 (Cp50s), which are equivalent to MACs of isoflurane, Cp50-noci, Cp50-extb, and Cp50-awake, respectively, were measured for propofol.

Results

MAC-noci and MAC-extb of isoflurane in marmosets were 1.91% and 1.38%, respectively. MAC-awake was not determined owing to technical difficulties. Cp50-noci, Cp50-extb, and Cp50-awake were 9.45, 7.21, and 3.54 μg/mL, respectively.

Conclusions

The obtained results refined existing isoflurane and propofol for sedation and anesthesia in marmosets.

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来源期刊

Journal of Medical Primatology 生物-动物学

CiteScore

1.40

自引率

42.90%

发文量

审稿时长

6 months

期刊介绍： The Journal of Medical Primatology publishes research on non-human primates as models to study, prevent, and/or treat human diseases; subjects include veterinary medicine; morphology, physiology, reproductive biology, central nervous system, and cardiovascular diseases; husbandry, handling, experimental methodology, and management of non-human primate colonies and laboratories; non-human primate wildlife management; and behaviour and sociology as related to medical conditions and captive non-human primate needs. Published material includes: Original Manuscripts - research results; Case Reports - scientific documentation of a single clinical study; Short Papers - case histories, methodologies, and techniques of particular interest; Letters to the Editor - opinions, controversies and sporadic scientific observations; Perspectives – opinion piece about existing research on a particular topic; Minireviews – a concise review of existing literature; Book Reviews by invitation; Special Issues containing selected papers from specialized meetings; and Editorials and memoriams authored by the Editor-in-Chief.