Exploring the Interplay of Factors in Chronic Kidney Disease: Insights from The Malaysian Cohort Study.

IF 2.1 4区医学 Q2 PERIPHERAL VASCULAR DISEASE Kidney & blood pressure research Pub Date : 2025-01-01 Epub Date: 2025-02-20 DOI:10.1159/000542732

Noraidatulakma Abdullah, Norfazilah Ahmad, Azmawati Mohammed Nawi, Mohd Rohaizat Hassan, Ying-Xian Goh, Norliza Ismail, Nazihah Abd Jalal, Raihannah Othman, Azwa Shawani Kamalul Arifin, Mohd Arman Kamaruddin, Rahman Jamal

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Abstract

Introduction: There is an increasing prevalence of chronic kidney disease (CKD) in Malaysia; hence, identifying factors associated with the early stage of CKD is crucial for preventive measures. This study investigated the association between various factors and their interaction in a multi-ethnic Malaysian cohort.

Methods: A nested case-control analysis was conducted on 3,160 eligible participants with renal profile data from The Malaysian Cohort project. CKD status was determined by estimated glomerular filtration rate using the Chronic Kidney Disease Epidemiology Collaboration equation. Multiple logistic regression analysis using the likelihood ratio method was used to identify the factors and their interaction with CKD.

Results: This study suggested five factors associated with CKD: gender, ethnicity, physical activity, atherogenic plasma index (AIP), and systolic blood pressure. There was an interaction between AIP and gender, with increased odds of CKD among men with high AIP.

Conclusions: As CKD is mainly asymptomatic until it is in the later stages, these five factors serve as valuable tools for predicting CKD and enhancing the identification of at-risk individuals, particularly among men with elevated AIP. Future studies should focus on using these factors, especially in preventing new CKD cases and their progression.

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探索慢性肾脏疾病因素的相互作用：来自马来西亚队列研究的见解。

马来西亚的慢性肾脏疾病（CKD）患病率越来越高，因此确定与早期CKD相关的因素对于预防措施至关重要。本研究调查了马来西亚多民族人群中各种因素之间的关系及其相互作用。方法：对来自马来西亚队列项目的3160名符合条件的参与者进行巢式病例对照分析。使用慢性肾脏疾病流行病学合作（CKD- epi）方程，通过估算肾小球滤过率（eGFR）来确定CKD状态。采用似然比法进行多元logistic回归分析，以确定CKD的影响因素及其相互作用。结果：本研究提示了与CKD相关的五个因素：性别、种族、体力活动、动脉粥样硬化血浆指数（AIP）和收缩压。AIP与性别之间存在相互作用，AIP高的男性患CKD的几率增加。结论：由于CKD在晚期之前主要是无症状的，因此这五个因素可以作为预测CKD和增强危险个体识别的有价值的工具，特别是在血浆动脉粥样硬化指数（AIP）升高的男性中。未来的研究应侧重于利用这些因素，特别是在预防新的CKD病例及其进展方面。

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来源期刊

Kidney & blood pressure research 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal comprises both clinical and basic studies at the interface of nephrology, hypertension and cardiovascular research. The topics to be covered include the structural organization and biochemistry of the normal and diseased kidney, the molecular biology of transporters, the physiology and pathophysiology of glomerular filtration and tubular transport, endothelial and vascular smooth muscle cell function and blood pressure control, as well as water, electrolyte and mineral metabolism. Also discussed are the (patho)physiology and (patho) biochemistry of renal hormones, the molecular biology, genetics and clinical course of renal disease and hypertension, the renal elimination, action and clinical use of drugs, as well as dialysis and transplantation. Featuring peer-reviewed original papers, editorials translating basic science into patient-oriented research and disease, in depth reviews, and regular special topic sections, ''Kidney & Blood Pressure Research'' is an important source of information for researchers in nephrology and cardiovascular medicine.