Lie-Feng Ma , Shan-Rong Luo , Qian-Qing Liu , Rui-Si Tang , Ning-Yu Chen , Di Luo , Lu Guo , Jia Li , Rui Wu , Zha-Jun Zhan
{"title":"Neuroprotective lindenane sesquiterpenoids from the roots of Lindera aggregata (Sims) Kosterm","authors":"Lie-Feng Ma , Shan-Rong Luo , Qian-Qing Liu , Rui-Si Tang , Ning-Yu Chen , Di Luo , Lu Guo , Jia Li , Rui Wu , Zha-Jun Zhan","doi":"10.1016/j.phytochem.2025.114452","DOIUrl":null,"url":null,"abstract":"<div><div>Eleven previously undescribed lindenane sesquiterpenoids, lindaggrols A−K (<strong>1</strong>−<strong>11</strong>), were isolated from the roots of <em>Lindera aggregata</em> (Sims) Kosterm, together with five known ones. Their structures were elucidated by HR-ESI-MS, NMR, and single-crystal X-ray diffraction analyses. Lindaggrol A (<strong>1</strong>) is an undescribed rearranged dinor-lindenane with an unprecedented 3/5/5 tricyclic scaffold. All isolated compounds were assayed for their neuroprotective effects against erastin-induced ferroptosis in HT-22 cells. Among them, <strong>3</strong>, <strong>12</strong> and <strong>14</strong> exhibited significant neuroprotective activities with EC<sub>50</sub> values ranging from 1.4 to 8.7 μM.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"235 ","pages":"Article 114452"},"PeriodicalIF":3.2000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942225000755","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Eleven previously undescribed lindenane sesquiterpenoids, lindaggrols A−K (1−11), were isolated from the roots of Lindera aggregata (Sims) Kosterm, together with five known ones. Their structures were elucidated by HR-ESI-MS, NMR, and single-crystal X-ray diffraction analyses. Lindaggrol A (1) is an undescribed rearranged dinor-lindenane with an unprecedented 3/5/5 tricyclic scaffold. All isolated compounds were assayed for their neuroprotective effects against erastin-induced ferroptosis in HT-22 cells. Among them, 3, 12 and 14 exhibited significant neuroprotective activities with EC50 values ranging from 1.4 to 8.7 μM.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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