{"title":"Synthesis, Complexation with Pd(II), and Cytotoxicity of Pyridin-3-Ylmethylylidene Derivatives of Methyl Betulonate","authors":"M. S. Denisov, A. O. Voronina, O. A. Maiorova","doi":"10.1007/s10600-025-04584-8","DOIUrl":null,"url":null,"abstract":"<p>Pyridin-3-ylmethylylidene derivatives of methyl betulonate were synthesized. Six new Pd(II) complexes of them were obtained. The effects of these compounds on A549 (non-small-cell lung carcinoma) and HCT116 cell lines (colon cancer) were assessed by the MTT assay. 3-{(<i>E</i>)-[28-Methoxy-3,28-dioxolup-20(29)-en-2-ylidene]methyl}-1-methylpyridinium tetrafluoroborate exhibited potent cytotoxic activity on HCT116 cell line (IC<sub>50</sub> = 7.21 μM).</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"104 - 110"},"PeriodicalIF":0.9000,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-025-04584-8","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Pyridin-3-ylmethylylidene derivatives of methyl betulonate were synthesized. Six new Pd(II) complexes of them were obtained. The effects of these compounds on A549 (non-small-cell lung carcinoma) and HCT116 cell lines (colon cancer) were assessed by the MTT assay. 3-{(E)-[28-Methoxy-3,28-dioxolup-20(29)-en-2-ylidene]methyl}-1-methylpyridinium tetrafluoroborate exhibited potent cytotoxic activity on HCT116 cell line (IC50 = 7.21 μM).
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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