Transcranial direct current stimulation for cognitive rehabilitation in people with multiple sclerosis: A systematic review of randomized controlled trials.
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Abstract
People with multiple sclerosis (PwMS) often experience cognitive impairments that affect independence in their activities. Transcranial direct current stimulation (tDCS) has been recently used for treating cognitive impairments in patients with neurological conditions. This review aims to investigate the effects of tDCS on cognitive function in PwMS. Databases including "PubMed, SCOPUS, MEDLINE, EMBASEe, and Web of Science" were searched until July 2024. The risk of bias was evaluated using the Cochrane Collaboration tool (CCT). Nine were selected for inclusion in this review, encompassing 274 PwMS, 77.74% of whom were females. Five studies have a low risk of bias, while four have a moderate risk of bias on the CCT. The findings revealed mixed evidence regarding the effects of tDCS on cognitive function in PwMS. In conclusion, most studies have shown that tDCS does not improve various cognitive domains in PwMS. However, due to the limited number of studies and their high heterogeneity, further research is needed to assess the immediate and long-term impacts of tDCS on numerous cognitive domains in PwMS, understand the relationship between PwMS characteristics and their response to the tDCS intervention, and define the optimal tDCS treatment protocols for treating cognitive impairments in PwMS.
期刊介绍：
pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.
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