Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis.

IF 7.9 2区 医学 Q1 IMMUNOLOGY Mucosal Immunology Pub Date : 2025-02-21 DOI:10.1016/j.mucimm.2025.02.003
Flávia M Saavedra, Danielle B Brotto, Vineet Joag, Courtney A Matson, Mark C Herzberg, Pavel P Nesmiyanov, Vaiva Vezys, David Masopust, J Michael Stolley
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引用次数: 0

Abstract

Emerging evidence indicates that gingival-resident helper CD4+ T cells are major drivers of periodontal inflammation in response to commensal and pathogenic oral microorganisms. Whether tissue-resident memory CD8+ T cells (TRM), which principally safeguard against viruses and cancer but also drive certain autoimmune and inflammatory conditions, impact periodontitis progression and severity remain unknown. We asked whether local reactivation of oral CD8+ TRM of a defined antigen specificity could exacerbate ligature-induced periodontitis (LIP), a well-established model of periodontal disease in mice. Topical application of virus-mimicking peptides to the oral mucosa concurrent with LIP 1) intensified alveolar bone loss, 2) amplified gingival and cervical lymph node inflammation, and 3) stimulated gingival transcriptional changes in genes related to innate immune sensing and cell-mediated cytotoxicity. Therapeutic depletion of CD103-expressing oral CD8+ TRM in advance of LIP prevented exacerbation of disease. These observations provide evidence that oral CD103+ CD8+ TRM have the potential to participate in gingival inflammation, alveolar bone loss, and periodontitis.

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来源期刊
Mucosal Immunology
Mucosal Immunology 医学-免疫学
CiteScore
16.60
自引率
3.80%
发文量
100
审稿时长
12 days
期刊介绍: Mucosal Immunology, the official publication of the Society of Mucosal Immunology (SMI), serves as a forum for both basic and clinical scientists to discuss immunity and inflammation involving mucosal tissues. It covers gastrointestinal, pulmonary, nasopharyngeal, oral, ocular, and genitourinary immunology through original research articles, scholarly reviews, commentaries, editorials, and letters. The journal gives equal consideration to basic, translational, and clinical studies and also serves as a primary communication channel for the SMI governing board and its members, featuring society news, meeting announcements, policy discussions, and job/training opportunities advertisements.
期刊最新文献
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice. Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis. Lung-resident memory Th2 cells regulate pulmonary cryptococcosis by inducing type-II granuloma formation. Influenza virus-induced type I interferons disrupt alveolar epithelial repair and tight junction integrity in the developing lung. IL-6 mediates defense against influenza virus by promoting protective antibody responses but not innate inflammation.
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