GABA as hydrophilic emulsifier for W/O/W double emulsion: Co-delivering anti-anxiety compounds GABA and quercetin

IF 5.2 2区化学 Q2 CHEMISTRY, PHYSICAL Journal of Molecular Liquids Pub Date : 2025-05-01 Epub Date: 2025-02-22 DOI:10.1016/j.molliq.2025.127221

Meng-Qi Liu , Ling Li , Bo-Hao Liu , Jie Zhou , Bao-Rong Wang , Ying-Hua Zhang , Zhi-Shen Mu

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Abstract

Quercetin and γ-aminobutyric acid (GABA) are two compounds with anti-anxiety properties. But the insolubility of quercetin and the low extraction rate of GABA from plants have been major issues limiting their application. Therefore, GABA in kidney beans was enriched through the application of ultrasound and calcium chloride-induced stress, and the enriched GABA was used as a substitute for surfactant to prepare water-in-oil-in-water (W/O/W) double emulsion. The coexistence of the water and oil phases in the double emulsion facilitates the simultaneous delivery of quercetin (hydrophobic) and GABA (hydrophilic). The results showed that GABA has good surfactant capacity and can form a stable double emulsion when it partially replaces Tween 80 in the outer aqueous phase. Under these conditions, the double emulsion had better encapsulation efficiency for quercetin and GABA (quercetin: 86.66 %, GABA: 91.01 %), improved the stability of gastrointestinal simulation, obtained high bioavailability and anti-anxiety effects.

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GABA作为W/O/W双乳液的亲水性乳化剂：共同递送抗焦虑化合物GABA和槲皮素

槲皮素和γ-氨基丁酸（GABA）是两种具有抗焦虑作用的化合物。但槲皮素的不溶性和植物中GABA的提取率低一直是制约其应用的主要问题。因此，通过超声波和氯化钙诱导胁迫对芸豆中的GABA进行富集，并用富集后的GABA代替表面活性剂制备油包水（W/O/W）双乳液。双乳液中水相和油相共存，有利于槲皮素（疏水）和GABA（亲水）的同时传递。结果表明，GABA具有良好的表面活性剂性能，在部分取代Tween 80的外水相中可形成稳定的双乳液。在此条件下，双乳对槲皮素和GABA具有较好的包封效率（槲皮素：86.66%,GABA: 91.01%），提高了胃肠模拟的稳定性，获得了较高的生物利用度和抗焦虑作用。

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来源期刊

Journal of Molecular Liquids 化学-物理：原子、分子和化学物理

CiteScore

10.30

自引率

16.70%

发文量

2597

审稿时长

78 days

期刊介绍： The journal includes papers in the following areas: – Simple organic liquids and mixtures – Ionic liquids – Surfactant solutions (including micelles and vesicles) and liquid interfaces – Colloidal solutions and nanoparticles – Thermotropic and lyotropic liquid crystals – Ferrofluids – Water, aqueous solutions and other hydrogen-bonded liquids – Lubricants, polymer solutions and melts – Molten metals and salts – Phase transitions and critical phenomena in liquids and confined fluids – Self assembly in complex liquids.– Biomolecules in solution The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include: – Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.) – Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.) – Light scattering (Rayleigh, Brillouin, PCS, etc.) – Dielectric relaxation – X-ray and neutron scattering and diffraction. Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.