Incidence and Characteristics of Pediatric Eosinophilic Esophagitis: A Midwestern State Analysis.

IF 2 4区医学 Q2 PEDIATRICS Children-Basel Pub Date : 2025-02-19 DOI:10.3390/children12020248

Jose L Zamora-Sifuentes, Andrew Rorie, Sharad Kunnath, Rosemary Pauley, Andrew Huang Pacheco, Russell Hopp

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Abstract

Background: Eosinophilic esophagitis (EoE) is a chronic disease defined by esophageal dysfunction and >15 eosinophils per high-power-field on biopsy. Despite its increased incidence across the United States, studies evaluating its incidence at any state level are lacking.

Methods: Record review of pediatric patients (<18 years) newly diagnosed with EoE based on ICD coding seen at the main two pediatric gastroenterology centers in the state: Children's Nebraska (1 January 2016-31 December 2022) and Boys Town National Research Hospital (1 January 2022-31 December 2022). Data included demographics, age, and zip codes. Descriptive analysis focused on Nebraska residents.

Results: The average point incidence of EoE between 2016 and 2022 was 10.84/100,000 inhabitants based on data from Children's Nebraska. Considering both centers, the point incidence in Nebraska for 2022 was 32.45/100,000 inhabitants. Caucasians were 3.7 times more likely to be affected and older at time of diagnosis (average 9.7 years) compared to African Americans (7.0), Hispanics (7.4), and Asians (4.4).

Conclusions: This is the first study evaluating the incidence of EoE in a specific U.S.A state. Studies at the state level are important to direct policy and interventions aiming limit its burden in communities.

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背景：嗜酸性粒细胞食管炎（EoE）是一种慢性疾病，表现为食管功能障碍和活检时每高倍视野中嗜酸性粒细胞数大于 15 个。尽管这种疾病在美国的发病率越来越高，但却缺乏在任何州一级对其发病率进行评估的研究：方法：对儿科患者的记录进行回顾（结果：嗜酸性粒细胞增多症的平均发病率为 0.5%，而嗜碱性粒细胞增多症的平均发病率为 0.5%）：根据内布拉斯加州儿童医院的数据，2016 年至 2022 年间，肠易激综合征的平均发病率为 10.84/100,000。考虑到两个中心的数据，2022年内布拉斯加州的发病率为32.45/100,000人。与非裔美国人（7.0）、西班牙裔美国人（7.4）和亚裔美国人（4.4）相比，白种人受影响的可能性要高出3.7倍，而且在确诊时年龄更大（平均9.7岁）：这是首次对美国特定州的肠易激综合征发病率进行评估的研究。州一级的研究对于指导政策和干预措施以限制其在社区造成的负担非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Children-Basel PEDIATRICS-

CiteScore

2.70

自引率

16.70%

发文量

1735

审稿时长

6 weeks

期刊介绍： Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.