Assessment of cellular dose and damage induced by radon and its progeny using the BEAS-2B cell mesh model

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Applied Radiation and Isotopes Pub Date : 2025-02-21 DOI:10.1016/j.apradiso.2025.111749

Han Gao , Yidi Wang , Jiahao Guo , Huiyuan Xue , Xinjie Wang , Kaijin Yan , Tao Wu , Xiaotong Gao , Haiyang Li , Liang Sun

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Abstract

The decay of radon and its progeny mainly produces α particles and β particles. Due to their short range and high linear energy transfer (LET) of α particles, it is necessary to evaluate the dose deposition at the cellular and subcellular levels so as to better assess their health effects on the human body. Given that the lung is the primary target organ for radon exposure, we utilized human bronchial epithelial cells (BEAS-2B cells) to construct a realistic mesh model. Using Monte Carlo simulation software PHITS, we computed cellular S-values under conditions of radon and progeny irradiation, the deposited does inside cells of nuclide that distribute outside cells has been calculated. These calculations were contrasted with results obtained from traditional geometric models and MIRDcell calculations. To quantify the damage effects caused by radon and its progeny, this study used MCDS to calculate the DNA damage, for various nuclides, Rn-222 produces the highest number of double-strand breaks (DSBs) up to 21.8 Gy-1cell-1, while Tl-210 produces the least DSBs with 8.32 Gy-1cell-1. Additionally, other damage metrics such as single-strand breaks (SSBs), “OTHER”, and “ALL CLUSTERS” were quantified. This research, based on the BEAS-2B cell model, offers more precise information on cellular doses and damage effects of radon and its progeny. It holds significant implications for the future development of radiation protection strategies and applications in radon therapy.

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.