Cardiovascular disease risk prediction and profiling among Asian Indians with young-onset type 1 and type 2 diabetes.

IF 3.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Diabetic Medicine Pub Date : 2025-02-28 DOI:10.1111/dme.70020

Sengottuvelu Aswath Krishna, Ulagamathesan Venkatesan, Anandakumar Amutha, Saravanan Jebarani, Gunasekaran Sengottuvelu, Ranjit Unnikrishnan, Viswanathan Mohan, Ranjit Mohan Anjana

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Abstract

Aims: This study aims to describe the profile of Asian Indians with young-onset type 1 diabetes (T1D) and type 2 diabetes (T2D) who have 'low cardiovascular disease (CVD) risk' and 'high CVD risk' based on QRESEARCH risk estimator version 3(QRISK3) and Framingham Risk Score (FRS). It also aims to assess the predictive ability of these risk calculators to estimate CVD risk in this population.

Methods: Retrospective data of 18,837 individuals with T1D or T2D with an age of onset of between 10 to 30 years were retrieved from Diabetes Electronic Medical Records. QRISK3 algorithm and FRS were used to estimate the 10-year risk of CVD. After excluding individuals with preexisting CVD (n = 175), the QRISK3 score was calculated for 5371, and FRS for 7444 individuals with young-onset T1D and T2D. CVD risk was categorized as high if the QRISK3 and FRS scores ≥10.0% and low, if <10.0%.

Results: Among individuals with T1D,17.3% had high QRISK3 scores and 19.0% had high FRS scores. Among individuals with T2D, 31.9% had high QRISK3 scores and 37.2% had high FRS scores. Individuals with T2D had a higher risk than those with T1D by both risk scores (p < 0.001). The frequency of high-risk scores increased with age and was higher among men. The receiver operating characteristic-area under the curve (ROC-AUC) showed that both scores (QRISK3-0.788; FRS-0.746; p = 0.241) predicted 10-year cardiovascular disease risk well.

Conclusion: Both QRISK and FRS were good predictors of CVD in this population. Individuals with young-onset diabetes have a high propensity to develop cardiovascular disease within 10 years, with T2D having a higher risk than T1D. Regular risk monitoring, lifestyle modifications and medical interventions are essential among individuals with young-onset T2D and T1D.

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来源期刊

Diabetic Medicine 医学-内分泌学与代谢

CiteScore

7.20

自引率

5.70%

发文量

229

审稿时长

3-6 weeks

期刊介绍： Diabetic Medicine, the official journal of Diabetes UK, is published monthly simultaneously, in print and online editions. The journal publishes a range of key information on all clinical aspects of diabetes mellitus, ranging from human genetic studies through clinical physiology and trials to diabetes epidemiology. We do not publish original animal or cell culture studies unless they are part of a study of clinical diabetes involving humans. Categories of publication include research articles, reviews, editorials, commentaries, and correspondence. All material is peer-reviewed. We aim to disseminate knowledge about diabetes research with the goal of improving the management of people with diabetes. The journal therefore seeks to provide a forum for the exchange of ideas between clinicians and researchers worldwide. Topics covered are of importance to all healthcare professionals working with people with diabetes, whether in primary care or specialist services. Surplus generated from the sale of Diabetic Medicine is used by Diabetes UK to know diabetes better and fight diabetes more effectively on behalf of all people affected by and at risk of diabetes as well as their families and carers.”