Immunostimulating Staphylococcal Lipoteichoic Acid Prevents Pulmonary Tumor Colonization in BALB/c-Mice

Abstract

Immunostimulating and antineoplastic activities of staphylococcal lipoteichoic acid (LTA) were studied in Balb/c-mice. Systemic administration of LTA (1 mg or 2 mg i.p., 7 and 4 days prior to challenge) significantly enhanced chemiluminescence response of peritoneal macrophages (p < 0.0125) and induced enlargement of the spleen (p < 0.025) as compared to non-treated controls. In vivo the number of lung colonies was significantly lower (p < 0.0125) in LTA-treated mice 14 days after challenge with L-1 sarcoma cells.