Seungmin Ha , Seogjin Kang , Mooyoung Jung , Ui-Hyung Kim
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引用次数: 0
Abstract
Infectious bovine rhinotracheitis (IBR), caused by bovine alphaherpesvirus 1 (BoAHV1), is a major viral disease affecting cattle worldwide. Passive immunity from colostrum is crucial for protecting neonatal calves; however, maternally derived antibodies can interfere with vaccine efficacy, making it vital to understand their dynamics to optimize vaccination timing. This study examined the persistence of IBR-specific antibodies in 55 Jersey calves from birth to 12 weeks of age (pre-vaccination stage) and analyzed factors influencing antibody levels. Multiple linear regression analyses were conducted to evaluate the effects of dam breed, parity, IBR reactivity, gestation length, calf sex, and birth weight on IBR reactivity in calves at 12 weeks. The results revealed that Jersey calves exhibited high IBR reactivity levels at birth, which gradually declined over the 12-week period. Dam breed, parity, and IBR reactivity at calving significantly influenced calf IBR reactivity levels at 12 weeks of age (p < 0.05). Calves that received colostrum from Holstein Friesian dams, higher-parity dams, or dams with elevated serum IBR reactivity exhibited higher IBR reactivity levels at 12 weeks of age. These findings highlight the critical role of maternal factors in shaping passive immunity and underscore the need for further research into colostrum quality and antibody absorption to improve vaccination strategies.
期刊介绍：
The journal reports basic, comparative and clinical immunology as they pertain to the animal species designated here: livestock, poultry, and fish species that are major food animals and companion animals such as cats, dogs, horses and camels, and wildlife species that act as reservoirs for food, companion or human infectious diseases, or as models for human disease.
Rodent models of infectious diseases that are of importance in the animal species indicated above,when the disease requires a level of containment that is not readily available for larger animal experimentation (ABSL3), will be considered. Papers on rabbits, lizards, guinea pigs, badgers, armadillos, elephants, antelope, and buffalo will be reviewed if the research advances our fundamental understanding of immunology, or if they act as a reservoir of infectious disease for the primary animal species designated above, or for humans. Manuscripts employing other species will be reviewed if justified as fitting into the categories above.
The following topics are appropriate: biology of cells and mechanisms of the immune system, immunochemistry, immunodeficiencies, immunodiagnosis, immunogenetics, immunopathology, immunology of infectious disease and tumors, immunoprophylaxis including vaccine development and delivery, immunological aspects of pregnancy including passive immunity, autoimmuity, neuroimmunology, and transplanatation immunology. Manuscripts that describe new genes and development of tools such as monoclonal antibodies are also of interest when part of a larger biological study. Studies employing extracts or constituents (plant extracts, feed additives or microbiome) must be sufficiently defined to be reproduced in other laboratories and also provide evidence for possible mechanisms and not simply show an effect on the immune system.
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