A steady-state MR fingerprinting sequence optimization framework applied to the fast 3D quantification of fat fraction and water T1 in the thigh muscles.

IF 3 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Magnetic Resonance in Medicine Pub Date : 2025-03-04 DOI:10.1002/mrm.30490

Constantin Slioussarenko, Pierre-Yves Baudin, Benjamin Marty

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引用次数: 0

Abstract

Purpose: The aim of this study was to develop an optimization framework to shorten GRE-based MRF sequences while keeping similar parameter estimation quality.

Methods: An optimization framework taking into account steady-state initial longitudinal magnetization, undersampling artifacts, and mitigating overfitting by drawing from a realistic numerical thighs phantom database was developed and validated on numerical simulations and 10 healthy volunteers.

Results: The sequences optimized with the proposed framework decreased the original sequence duration by 30% (8 s per repetition instead of 11.2 s) while showing improved accuracy (SSIM going up from 96% to 99% for $F F$ , from 93% to 96% for $T 1_{H 2 O}$ on numerical simulations) and precision, especially when compared with sequences optimized through other means.

Conclusions: The proposed framework paves the way for fast 3D quantification of $F F$ and $T 1_{H 2 O}$ in the skeletal muscle.

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来源期刊

Magnetic Resonance in Medicine 医学-核医学

CiteScore

6.70

自引率

24.20%

发文量

376

审稿时长

2-4 weeks

期刊介绍： Magnetic Resonance in Medicine (Magn Reson Med) is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications. Reports of original investigations in the areas of mathematics, computing, engineering, physics, biophysics, chemistry, biochemistry, and physiology directly relevant to magnetic resonance will be accepted, as well as methodology-oriented clinical studies.