Prevalence of Latent Tuberculosis Infection in Multiple Sclerosis Patients from an Endemic Country: A Cross-Sectional Study

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY Multiple sclerosis and related disorders Pub Date : 2025-03-01 DOI:10.1016/j.msard.2025.106354

Simón Cárdenas-Robledo , Juan Camilo Carrillo-Martinez , María Isabel Zuluaga , Jairo Quiñones-Bautista , Valeria Valencia-Cifuentes , Erika Paola Vergara-Vela , Cristian Eduardo Navarro , Lorena López-Reyes , Laura Estefanía Arenas-Vargas

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Abstract

Background

MS patients are at increased risk for tuberculosis reactivation due to immunosuppressive therapies. Prevalence of latent tuberculosis in MS from our country is unknown.

Objective

To assess the prevalence and determinants of latent tuberculosis infection (LTBI) in MS patients from Colombia.

Methods

Multicentric, cross-sectional, retrospective study involving confirmed MS patients. LTBI was defined as a positive tuberculin skin test in asymptomatic patients with normal chest imaging. The prevalence (95 %CI) of LTBI was estimated and compared to the general prevalence with a one-sample proportion test. Determinants of LTBI were analysed using adjusted logistic regression.

Results

481 patients were included, with a mean age of 42 years and a mean MS duration of 10 years. The prevalence of LTBI was 6.24 % (95 %CI: 4.25–8.78), significantly lower than that of the general population (21.11 %; p < 0.001). Male sex (OR: 2.52; 95 %CI: 1.00–6.28, p = 0.046) was independently associated with LTBI.

Conclusion

LTBI is significantly less prevalent among our sample compared to the general population, and is associated with male sex.

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.