Achieved fluidized crystal coating of aspirin by ensuring core stability and minimizing drug migration within the sustained layer

IF 4.5 2区工程技术 Q2 ENGINEERING, CHEMICAL Powder Technology Pub Date : 2025-03-01 DOI:10.1016/j.powtec.2025.120863

Yupeng Feng , Xin Liu , Zilin Song , Tong Liu , Zixu Liu , Peifu Xiao , Tian Yin , Yu Zhang , Haibing He , Jingxin Gou , Yanjiao Wang , Xing Tang

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Abstract

In this study, the fluidized crystal coating (FCC) method was proposed to prepare aspirin sustained-release capsules (ASC). The properties of aspirin crystals and their respective coating solutions were systematically investigated. Additionally, the crystal properties of aspirin (ASP) were analyzed by evaluating the contact angle and solid surface characteristics. The surface energy of the crystals before and after the coating process was also measured, providing essential insights into the preparation process. Pellets with coating weight gains of 2 % to 4 % (Part A) and 14 % to 17 % (Part B) were mixed in a 3:7 ratio to obtain the ASC. The resulting ASC exhibited a clear sustained-release effect. Nanoindentation experiments offered critical data supporting the FCC coating process and provided practical guidance for the operation of the coating process. Furthermore, Raman spectroscopy and TEM were employed to investigate the structure of the coated crystals. DSC and XRD analyses confirmed that the aspirin crystals did not undergo any crystallographic changes during the process. The combined results of these experiments demonstrate that the preparation of ASC using the FCC method is feasible and provides a new approach for the FCC coating process.

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来源期刊

Powder Technology 工程技术-工程：化工

CiteScore

9.90

自引率

15.40%

发文量

1047

审稿时长

46 days

期刊介绍： Powder Technology is an International Journal on the Science and Technology of Wet and Dry Particulate Systems. Powder Technology publishes papers on all aspects of the formation of particles and their characterisation and on the study of systems containing particulate solids. No limitation is imposed on the size of the particles, which may range from nanometre scale, as in pigments or aerosols, to that of mined or quarried materials. The following list of topics is not intended to be comprehensive, but rather to indicate typical subjects which fall within the scope of the journal's interests: Formation and synthesis of particles by precipitation and other methods. Modification of particles by agglomeration, coating, comminution and attrition. Characterisation of the size, shape, surface area, pore structure and strength of particles and agglomerates (including the origins and effects of inter particle forces). Packing, failure, flow and permeability of assemblies of particles. Particle-particle interactions and suspension rheology. Handling and processing operations such as slurry flow, fluidization, pneumatic conveying. Interactions between particles and their environment, including delivery of particulate products to the body. Applications of particle technology in production of pharmaceuticals, chemicals, foods, pigments, structural, and functional materials and in environmental and energy related matters. For materials-oriented contributions we are looking for articles revealing the effect of particle/powder characteristics (size, morphology and composition, in that order) on material performance or functionality and, ideally, comparison to any industrial standard.