The temporal-insula type of temporal plus epilepsy patients with different postoperative seizure outcomes have different cerebral blood flow patterns

Abstract

Purpose

This study retrospectively analyzed preoperative arterial spin labeling (ASL) perfusion MRI data of patients with the temporal-insula type of temporal plus epilepsy (TI-TPE). We aimed to investigate the differences in presurgical cerebral blood flow (CBF) changes in TI-TPE patients with different surgical outcomes.

Method

A total of 48 TI-TPE patients confirmed by SEEG were meticulously reviewed for this study. Patients were divided into the seizure-free (SF) group (Engel IA) and the non-seizure-free (NSF) group (Engel IB to IV) according to the Engel seizure classification. The 3D-ASL data of all patients before surgery were analyzed using statistical parametric mapping (SPM) and graph theory analysis. These findings were then compared to healthy controls (HC) based on whole-brain voxel-level analysis and covariance network analysis.

Result

At the voxel-level, both SF and NSF groups showed significantly decreased CBF in the ipsilateral transverse temporal gyrus and insula (TTG/insula), contralateral middle cingulate gyrus, precuneus (MCG/precuneus), and increased CBF in the ipsilateral superior temporal gyrus and the superior temporal pole (STG/STP). Wherein the SF group showed more lower CBF in the contralateral MCG/precuneus, with unique increased CBF in the contralateral STG/insula and decreased CBF in the contralateral calcarine as well. In terms of network attributes, the NSF group showed a significantly higher clustering coefficient (Cp), global efficiency (Eglob), local efficiency (Eloc), shorter shortest path length (Lp), and more extensive abnormal nodes compared to the SF and HC groups. While the SF group has higher synchronicity than the HC group.

Conclusion

Both SF and NSF groups had abnormal CBF changes at the voxel and network levels with different patterns. The SF group showed more obvious regional CBF changes, while the NSF group showed more extended network disruption, which might underlie different seizure outcomes after local surgical resection.